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SESSION 6: Genomics and Molecular Advances in Meningioma
Saturday, June 18, 2016, 8:00am - 9:55am

 

Moderators: Houtan Noushmehr, Priscilla Brastianos

 

 


Molecular classification of meningiomas across all histological subtypes and grades
Felix Sahm*1,2, David TW Jones3, Daniel Schrimpf1, David Reuss1,2, David Capper1,2, Christian Kölsche1,2, Christian Mawrin4, Marcel Seiz5, Werner Paulus6, Stefan M Pfister3,7, Christel Herold-Mende8, Andreas von Deimling1
1Dept. of Neuropathology, Germany, 2CCU Neuropathology DKFZ, Germany, 3Div. of Pediatric Neurooncology DKFZ, Germany, 4Dept. of Neuropathology, Germany, 5Dept. of Neurosurgery, Germany, 6Institute of Neuropathology, Germany, 7Dept. Pediatric Oncology, Germany, 8Dept. of Neurosurgery, Germany
8:00am
Clonal selection toward TERT promoter mutations in progressive recurrent meningiomas
Tareq A Juratli*1, Matthias Kirsch1, Christian Thiede2, Dirk Daubner3, Dietmar Krex1,5, Mechthild Krause4,6, Priscilla BrastianoS7, Daniell P Cahill8, Gabrielle Schackert1,5
1Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany, 2Division of Hematology, Oncology and Stem Cell Transplantation, Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany, 3Department of Neuroradiology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany, 4Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Germany, 5German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Germany, 6Department of Radiation Oncology and OncoRay, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany, 7Department of Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, USA, 8Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, USA
8:15am
A patient with a secretory meningioma with a KLF4 mutation a novel TRAF7 mutation: Case report and characterization of functional consequences of TRAF7 mutations
Akash Patel*, Tiemo Klisch, Jean-Pierre Revelli, Huda Zoghbi
Baylor College of Medicine, USA
8:30am
Clinical impact of targeted amplicon sequence for meningioma as a practical clinical sequence system
Hiroshi Nishihara*1,2, Sayaka Yuzawa1, Shigeru Yamaguchi1, Hiromi Mohri1,3, Lei Wang1, Taichi Kimura1,2, Masumi Tsuda1, Mishie Tanino1, Hiroyuki Kobayashi1, Shunsuke Terasaka1, Kiyohiro Houkin2, Shinya Tanaka1
1Hokkaido University, Graduate School of Medicine, Japan, 2Hokkaido University Hospital, Japan, 3Hokuto Hospital, Japan
8:45am
Landscape of genomic alterations in high-grade meningiomas
Wenya Linda Bi1,3, Malak Abedalthagafi2, Noah Greenwald1,3, Pankaj Agarwalla3, Peleg Horowitz1,3, Will Gibson3,4, Ossama Al-Mefty1, Sandro Santagata2, Rameen Beroukhim3,4, Ian Dunn*1
1Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, USA, 2Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, USA, 3Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, USA, 4Broad Institute of MIT and Harvard, USA
9:00am
Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade
Christel Herold-Mende*1, Melissa Schmidt1, Andreas Mock1, Christin Jungk1, Felix Sahm2, Katrin Lamszus3, Ralf Ketter4, Almuth Kessler5, Mario Löhr5, Christian Senft6, Manfred Westphal3, Andreas von Deimling2, Andreas Unterberg1, Matthias Simon7
1University of Heidelberg, Dpt. Neurosurgery, Germany, 2Dpt. Neuropathology, CCU Neuropathology, DKTK, DKFZ, Germany, 3Dpt. Neurosurgery, University Medical Center Hamburg-Eppendorf, Germany, 4Dpt. Neurosurgery, Saarland University, Medical School, Germany, 5Dpt. Neurosurgery, University Hospital of Würzburg, Germany, 6Dpt. Neurosurgery, University of Frankfurt, Germany, 7Dpt. Neurosurgery, University Hospital Bonn, Germany
9:15am
Genetic characterization demonstrates high frequency of clinically actionable mutations in SMO and AKT1 in skull base meningiomas
Priscilla Brastianos*1, Matthew Strickland1, Corey Gill1, Naema Nayyar1, Megan D'Andrea1, Darrell Borger1, Sandro Santagata2, Matthew Frosch1, Daniel Cahill1, Frederick Barker1
1Massachusetts General Hospital, USA, 2Brigham and Women's Hospital, USA
9:25am
Transcriptomic analysis of meningiomas with or without deletion of chromosome 22q
Irineu Renzi, Marina Silveira, Andressa Rodrigues*, Marcella Rosa, Luciano Neder, Benedicto Colli, Daniela Tirapelli, Carlos Carlotti
Ribeirão Preto Medical School, University of São Paulo, Brazil
9:35am
Clinical next-generation sequencing in meningiomas
Katherine Schwetye*, Jamal Carter, Christina Tsien, Robert Schmidt, Albert Kim, Sonika Dahiya
Washington University School of Medicine, USA
9:45am