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SESSION 1: Tumor Biology: Animal Modeling and Cell Biology
Friday, June 17, 2016, 8:15am - 10:30am

 

Moderators: Michel Kalamarides, Gabriel Zada

  

Panel Discussion: Grace Pluhar, Gabriel Zada, Sameer Aghnihotri, Michel Kalamarides

 


Mouse models of meningioma tumorigenesis
M Kalamarides*1,3, J Boetto3, F Bielle2,3, M Peyre1,3
1Department of Neurosurgery, Hopital Pitie-Salpetriere, France, 2Department of Neuropathology, Hopital Pitie-Salpetriere, France, 3Inserm U1127, Institut Cerveau et Moelle Epiniere, France, 4Sorbonne University, France
8:15am
Clinical trial of autologous tumor lysate vaccines after surgical resection for the treatment of meningioma in dogs
G. Elizabeth Pluhar*, Matthew A. Hunt, Micheal R. Olin
University of Minnesota, USA
8:30am
Anti-tumor activity of CDK 4/6 inhibitor palbociclib in Rb+ meningioma: Pre-clinical assessment
Abhay K Varma*1, David Cachia1, Daniel G McDonald2, Vikram N Samant1, William A Vandergrift III1, Scott M Lindhorst1, Kenneth N Vanek2, Naren L Banik1,5, Joseph M Jenerette III2, Pierre Giglio3, Jeffrey J Raizer4, Sunil J. Patel1, Arabinda Das1
1Department of Neurosurgery and MUSC Brain & Spine Tumor Program, Medical University of South Carolina, USA, 2Department of Radiation Oncology, Medical University of South Carolina, USA, 3Department of Neurological Surgery, Ohio State University, USA, 4Department of Neurology, Northwestern Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, USA, 5Ralph H Johnson VA Medical Center, USA
8:45am
Comparative genomics: the dog as a translational model for meningioma
M. R. Chambers*1, Daxa M. Patel1, Kimberly P. Kicielinski1, Frank Crisona1, Dongquan Chen1, Trenton R. Schoeb1, Andy Shores3, Donald Sorjonen2, Calvin M. Johnson2, David K. Crossman1, G. Yancey Gillespie1
1University of Alabama at Birmingham, USA, 2Auburn University College of Veterinary Medicine, USA, 3Mississippi State University College of Veterinary Medicine, USA
9:00am
Combined multimodality treatment with hypoxia-activated prodrug TH-302 and XRT results in enhanced antitumor efficacy in preclinical malignant meningioma mouse model
Asif Maknojia*, Michael Garcia, David Cavazos, Courtney Bosse, Aleksandra Gruslova, Nikos Papanikolaou, Andrew Brenner, John Floyd
University of Texas Health Science Center at San Antonio, USA
9:10am
Radiosensitization of malignant meningioma cells with LB100, a protein phosphatase 2A inhibitor
Saman Sizdahkhani1, Winson S. Ho*1, Anita Tandle2, Nicole A. Colwell3, Shuyu Hao3, Dragan Maric4, Mones S. Abu-Asab5, Randy L. Jensen6, David L. Gillespie7, Mark R. Gilbert3, Zhengping Zhuang1, Deric M. Park3
1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, USA, 2Radiation Oncology Branch, National Cancer Institute, NIH, USA, 3Neuro-Oncology Branch, National Cancer Institute, NIH, USA, 4NINDS Flow Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, NIH, USA, 5Histopathology Core, National Eye Institute, NIH, USA, 6Department of Neurosurgery, Huntsman Cancer Institute, Department of Radiation Oncology, Department of Oncological Sciences, University of Utah, USA, 7Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, USA
9:20am
Dovitinib (TKI258), a multi-target angiokinase inhibitor, is effective regardless of NF Mutation status in meningioma
Abhay K Varma*1, David Cachia1, Vikram N. Samant1, Michele Decandio1, William A. Vandergrift III1, Scott M. Lindhorst1, Naren L. Banik1, Pierre Giglio2, Jeffrey J Raizer3, Sunil J. Patel1, Arabinda Das1
1Department of Neurosurgery and MUSC Brain & Spine Tumor Program, Medical University of South Carolina, USA, 2Department of Neurological Surgery, Ohio State University Wexner Medical College, USA, 3Department of Neurology and Northwestern Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, USA
9:30am
Patient-derived orthotopic malignant meningioma models for targeted virus therapy development
Fares Nigim, Shin-ichi Esaki, Michael Hood, Nina Lelic, Marianne James, Vijaya Ramesh, Anat Stemmer-Rachamimov, Daniel Cahill, Priscilla Brastianos, Samuel Rabkin, Robert Martuza, Hiroaki Wakimoto*
Massachusetts General Hospital, Harvard Medical School, USA
9:40am