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Title Index
4EBP1 participates in cisplatin resistance of human glioma cells through PI3K/AKT/mTOR pathway
Li Bie*, Cong Hua, Lei Liu, Hongyan Yuan
The First Hospital of Jilin University, China
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A bioinformatics evaluation of tumor-associated macrophages across 2 brain tumor types
Wan-Yee Teo*1,2, Sekar Karthik1, Seshachalam Veerabrahma Pratap1, Xiaonan Li3,4, Jianhe Shen3,4, M. Tarek Elghetany3,4, Kam-Man Hui1, Ching C Lau3,4
1Humphrey Oei Institute of Cancer Research, National Cancer Center Singapore, Singapore, 2KK Women’s & Children’s Hospital, Duke-NUS Singhealth Academic Partners in Medicine, Singapore, 3Texas Children’s Hospital, USA, 4Baylor College of Medicine, USA, 5Dan L. Duncan Cancer Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A feasibility and randomized phase II study of vorinostat, bevacizumab, or temozolomide during radiation followed by maintenance chemotherapy in newly-diagnosed pediatric high-grade glioma: Children’s Oncology Group study ACNS0822
Lindsey M. Hoffman*1, James Geller1, James Leach1, Daniel Boue2, Rachid Drissi1, Lu Chen3, Mark Krailo3, Atmaram Pai Panandiker4, Lionel Chow1, Daphne Haas-Kogan5, Sachin Jogal6, Marvin Nelson7, Reggie Jakacki9, Mark Kieran8, Kenneth Cohen10, Ian Pollack9, Amar Gajjar4, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2Dayton Children's Hospital, USA, 3Children's Oncology Group Statistics and Data Center, USA, 4St. Jude Children's Hospital Medical Center, USA, 5University of California San Francisco, USA, 6Midwest Children's Cancer Center, USA, 7Children's Hospital of Los Angeles, USA, 8Dana-Farber Cancer Institute, USA, 9Children's Hospital of Pittsburg, USA, 10Johns Hopkins University/Sidney Kimmel Cancer Center, USA
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
A humanized co-transplant xenograft mouse model, to study toxicity of drugs targeted against pediatric brain tumors
Sharareh Gholamin*1,2, Suzana Assad Kahn1,2, Rogelio Esparza2, Gregor Hutter1,2, Abdullah Feroze2, Irving L. Weissman1, Siddhartha S. Mitra1, Samuel H. Cheshier1
1Stanford , Institute of Stem Cell Biology and Regenerative Medicine, USA, 2Stanford, department of Neurosurgery, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A molecular biology and phase II study of Imetelstat (GRN163L) in children with recurrent or refractory central nervous system (CNS) malignancies: a Pediatric Brain Tumor Consortium Study 
Ralph Salloum*1, Trent Hummel1, Shiva-Senthil Kumar1, Kathleen Dorris8, Shaoyu Li2, Tong Lin2, Arzu Onar-Thomas2, Lili Miles1, Tina Toung-Poussaint3, Charles Stevenson1, Stewart Goldman4, Girish Dhall5, Roger Packer6, Paul Fisher7, Maryam Fouladi1, James Boyett2, Rachid Drissi1
1Cincinnati Children's Hospital Medical Center, USA, 2St. Jude Children's Research Hospital, USA, 3Boston Children's Hospital of Chicago, USA, 4Ann and Robert H. Lurie Children's Hospital, USA, 5Children's Hospital of Los Angeles, USA, 6Children's National Medical Center, USA, 7Lucille Packard Children's Hospital Stanford, USA, 8Children's Hospital of Colorado, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A novel mouse model of young adult glioblastoma: In vivo expression of mutated IDH1 (R132H) gene using the Sleeping Beauty Transposase System
Felipe J. Nunez*, Flor M. Mendez, Carl Koschmann, Alexandra Calinescu, Marta Dzaman, Pedro R. Lowenstein, Maria G. Castro
University of Michigan, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A piggyBac toolkit for rapid testing of putative pediatric GBM driver genes with extensions for investigating cells of recurrence
Joshua Breunig*, Rachelle Levy, C. Danielle Antonuk, Jessica Molina-Aravena, Marina Dutra-Clarke, Aslam Akhtar, Gi Bum Kim, Hannah Park, Moise Danielpour
Cedars-Sinai, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A role for NADPH oxidase 4-generated reactive oxygen species in Sonic hedgehog-driven proliferation of cerebellar granule neuron precursors
Chad Potts*, Rachel Rotenberry, Anna Kenney
Emory University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A role of spindle cells in glioblastoma growth
Shoko Yamada1, Lue Sun2, Shokei Yamada*3
1Teikyo University Mizonokuchi Hospital, Japan, 2Tsukuba University, Japan, 3Loma Linda University School of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A scFv-based CAR to redirect T cells to IL13Rα2-positive pediatric glioma
Giedre Krenciute*1, Simone Krebs1, David Torres1, Maciej Lesniak2, Irina Balyasnikova2, Stephen Gottschalk1
1Baylor College of Medicine, USA, 2University of Chicago, USA
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
A standardized autopsy procurement allows for the comprehensive study of DIPG biology
Madhuri Kambhampati1, Jenifer Perez1, Sridevi Yadavilli1, Amanda Saratsis1,2, Ashley Hill1, Cheng-Ying Ho1, Eshini Panditharatna1,3, Melissa Markel4, Roger Packer1, Javad Nazarian*1,3
1Children's National Medical Center, USA, 2Ann & Robert H. Lurie Children’s Hospital of Chicago, USA, 3George Washington University, USA, 4Riley Hospital for Children, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Activated Wnt signaling targets Sox2+ treatment-refractory Shh-dependent medulloblastoma stem cells
Branavan Manoranjan*1, Chitra Venugopal1, Sujeivan Mahendram1, Steven Moreira1, Robin Hallett1, Thusyanth Vijayakumar1, David Bakhshinyan1, Nicole McFarlane1, John Hassell2, Bradley Doble1, Sheila Singh1,3
1McMaster Stem Cell & Cancer Research Institute, McMaster University, Canada, 2Department of Pathology & Molecular Medicine, Faculty of Health Sciences, McMaster University, Canada, 3Department of Surgery, Faculty of Health Sciences, McMaster University, Canada
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Activation of the IL6/STAT3 pathway in childhood ependymoma is associated with a pro-inflammatory tumor microenvironment and a poor prognosis
Andrea Griesinger*1,2, Rebecca Josephson1,2, Andrew Donson1,2, Jean Mulcahy Levy1,2, Vladimir Amani1,2, Diane Birks1,2, Lindsey Hoffman3, Rajeev Vibhakar1,2, Michael Handler1,2, Nicholas Foreman1,2
1University of Colorado Denver, Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA, 3Cincinnati Children's Hospital Medical Center, USA
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Aggressive medulloblastoma subverts the photoreceptor specific transcription factor NRL
Alexandra Garancher1, Morgane Morabito1, Nathalie Rocques1, Magalie Larcher1, Catherine Micquel2, Stéphanie Puget3, François Doz4, Olivier Delattre5, Olivier Ayrault1, Alain Eychène1, Franck Bourdeaut1, Celio Pouponnot*1
1Institut Curie/ CNRS UMR3347 / INSERM U1021, France, 2Universite Paris Descartes, France, 3Hopital Necker, France, 4Institut Curie / Service de Pédiatrie, France, 5Institut Curie / U830 INSERM, France
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
An animal model of 17p deletion in medulloblastoma
John Peacock*1,3, Anindya Bagchi4, Sean Egan3, Michael Taylor2,3
1The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Laboratory Medicine and Pathobiology, University of Toronto, Canada, 2Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children,, Canada, 3Developmental & Stem Cell Biology, The Hospital for Sick Children, Canada, 4University of Minnesota, USA
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Anti-tumor effect of trastuzumab, GM-CSF and IL-2 combinatorial therapy in pediatric ependymoma
Andrew Donson*1,2, Andrea Griesinger1,2, Diane Birks1,2, Vladimir Amani1,2, Jean Mulcahy-Levy1,2, Michael Handler1,2, Kathleen Dorris1,2, Nicholas Foreman1,2
1UCDenver, USA, 2Children's Hospital Colorado, USA
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Anti-tumor efficacy of adoptive cellular therapy is significantly increased by hematopoietic stem cells
Catherine Flores*, Christina Pham, Tyler Wildes, Rebecca Abraham, Jeffrey Drake, Duane Mitchell
University of Florida, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
ATRX loss promotes tumor growth and impairs genetic stability in glioblastoma
Carl Koschmann*1, Alexandra Calinescu1, Daniel Thomas1, Felipe J. Nunez1, Marta Dzaman1, Johnny Krasinkiewicz1, Neha Kamran1, Rosie Lemons1, Flor Mendez1, Youping Li1, David Ferguson1, Vera Gorbunova3, Soyeon Roh1, Lili Zhao1, Alan Meeker2, Pedro R. Lowenstein1, Maria G. Castro1
1University of Michigan, USA, 2Johns Hopkins University, USA, 3University of Rochester, USA
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Atypical Teratoid/Rhabdoid Tumour is a genetically homogeneous but epigenetically heterogeneous disease that is defined by subgroup specific super-enhancers
Pascal Johann1,2, Serap Erkek1, Marc Zapatka1, Kornelius Kerl1,3, Ivo Buchhalter1, Volker Hovestadt1, Andrey Korshunov4, Marina Rhyzova5, David T.W. Jones1, Paul A. Northcott1, Michael C. Frühwald6, Martin Hasselblatt7, Amar Gajjar8, Stefan M. Pfister1,2, Marcel Kool*1
1German Cancer Research Center, Germany, 2Department of Pediatric Hematology and Oncology, University Hospital, Germany, 3Department of Pediatric Hematology and Oncology, University Hospital, Germany, 4epartment of Neuropathology, University Hospital, Germany, 5NN Burdenko Neurosurgical Insitute, Russia, 6Swabian Childrens’ Cancer Center, Germany, 7Institute of Neuropathology, Germany, 8St Jude Children's Research Hospital, USA
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
Autophagy inhibition reverses resistance to targeted BRAF therapy in pediatric CNS tumors
Shadi Zahedi1, Andrea Griesinger1, Michael Handler2, Nicholas Foreman1, Andrew Thorburn1, Jean M. Mulcahy Levy*1
1University of Colorado Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Autopsy derived orthotopic xenograft (ADOX) mouse models for terminal pediatric brain tumors
Qi Li1, Patricia Baster1, Mari Kogiso1, Yuchen Du1, Holly Lindsay1, Zhigang Liu1, Xiumei Zhao1, Jack Su1, Adekunle Adesina1, Andrew Walter5, Jeffrey Murray2, Rene McNall-Knapp3, Javad Nazarian4, Will Parsons1, Murali Chintagumpala1, Susan Blaney1, Xiao-Nan Li*1
1Texas Children's Cancer Center, Baylor College of Medicine, USA, 2Cook Children's Hospital, USA, 3Jimmy Everest Center for Cancer and Blood Disorders in Children, USA, 4Children's National Mediacal Center, USA, 5duPont Hospital for Children, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Bcl-xL dependence of neural progenitors may be exploited to improve medulloblastoma therapy
Katherine Veleta*, Andrew Crowther, Timothy Gershon
University of North Carolina at Chapel Hill, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Biological consequences of histone mutations in the mammalian brain
Jon Larson*, Lawryn Kasper, Helen Russell, Chunxu Qu, Xiaoyan Zhu, Peter McKinnon, Suzanne Baker
St. Jude Children's Research Hospital, USA
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Boost volume effects on incidental hippocampal dose in pediatric medulloblastoma
Palak Kundu*, Iris Gibbs
Stanford University School of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma
Matthew Mistry*1, Nataliya Zhukova1, Daniele Merico1, Patricia Rakopoulos1, Rahul Krishnatry1, Mary Shago1, Jim Stavropoulos1, Jason Pole2, Peter Ray1, Marc Remke1, Pawel Buczkowicz1, Vijay Ramaswamy1, Adam Shlien1, James Rutka1, Peter Dirks1, Michael Taylor1, David Malkin1, Eric Bouffet1, Cynthia Hawkins1, Uri Tabori1
1The Hospital for Sick Children, Canada, 2Pediatric Oncology Group of Ontario, Canada
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Challenges in the management of hypothalamic juvenile pilocytic astrocytoma
William Gump*1,2, Ian Mutchnick1,2, Jennifer Elster1,3, Kanyalakshmi Ayyanar1,3
1Kosair Children's Hospital, USA, 2Norton Neuroscience Institute, USA, 3University of Louisville School of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Characterization of infiltrating myeloid cells associated with xenografted gliomas in the rodent brain
Josh Morganti, Sharon Liu, Susanna Rosi, Nalin Gupta*
University of California San Francisco, USA
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in myc-driven medulloblastoma
Eric Prince*, Monil Shah, Sujatha Venkataraman, Ilango Balakrishnan, Irina Alimova, Peter Harris, Diane Birks, Andrew Donson, Michael Taylor, Michael Handler, Nicholas Foreman, Rajeev Vibhakar
University of Colorado Anschutz Medical Campus, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Clinical, radiographic, and histologic characteristics of long-term survivors of diffuse intrinsic pontine glioma: a report from The International DIPG Registry
Lindsey M. Hoffman*1, Ute Bartels2, Lili Miles1, Cynthia Hawkins2, Stewart Goldman3, Sarah Leary4, Tim Hassal5, Jane Minturn6, Roger Packer7, Nicholas Foreman8, Kathy Warren9, Alberto Broniscer10, Emmett Broxon11, Chie-Schin Shih12, James Leach1, Blaise Jones1, Josh Baugh1, Brooklyn Hacker1, Brianna Lerme1, Chris Jones14, Sharon Savage9, Jenavieve Kirkendall1, Renee Doughman1, Matt Wollman1, Linwood Millett1, Rachel O'Keefe1, Eric Bouffet2, Dannis G. van Vuurden13, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2Hospital for Sick Children, Canada, 3Lurie Children's Hospital, USA, 4Seattle Children's Hospital, USA, 5Lady Cilento Children's Hospital, Australia, 6Children's Hospital of Philadelphia, USA, 7Children's National Medical Center, USA, 8Children's Hospital Colorado, USA, 9National Institute of Health, USA, 10St. Jude Children's Hospital Medical Center, USA, 11Dayton Children's Hospital, USA, 12Riley Children's Hospital, USA, 13VU University Medical Center, The Netherlands, 14Institute of Cancer Research, UK
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways
Torsten Pietsch*1, Barbara Steiger1, Dorota Denkhaus1, Christian Vokuhl2, Ivo Leuschner2
1Department of Neuropathology & Brain Tumor Reference Center, University of Bonn, Germany, 2Department of Pediatric Pathology & Kiel Pediatric Tumor Registry, University of Kiel, Germany
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Co-inhibition of the Sonic hedgehog and CXCR4 pathways uniquely blocks tumor initiating cell function in medulloblastoma
Stacey Ward*, Joshua Rubin
Washington University in St. Louis School of Medicine, USA
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
Combinatorial pathway targeting approaches for BRAF-fusions associated with pediatric low-grade gliomas
Angela Waanders1, Amanda Silva1, Shih-Shan Chen2, Harry Han2, Yuankun Zhu2, Katie Boucher2, Payal Jain*2, Tamara Fierst2, Namrata Choudhari2, Sabine Mueller3, Daphne Haas-Kogan4, Phillip Storm2, Adam Resnick2
1Division of Oncology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, The Children's Hospital of Philadelphia, USA, 2Department of Neurosurgery, University of Pennyslvania Perelman School of Medicine, The Children's Hospital of Philadelphia, USA, 3Department of Pediatrics, University of California, San Francisco, USA, 4Department of Radiation Oncology, University of California, San Francisco, USA
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated malignant brain tumors in children
Adam Shlien1,2, Brittany B. Campbell*1,3, Richard de Borja1, Ludmil B. Alexandrov4, Diana M. Merino1, Marc Remke3, Doua Bakry5, Peter Dirks3,6, Annie Huang3,5, Richard G. Grundy9, Carol Durno7,13, Melyssa Aronson7, Michael D. Taylor3,6, Zachary F. Pursell8, Christopher E. Pearson1,10, David Malkin1,5, Eric Bouffet3,5, Cynthia Hawkins3,11, Peter J. Campbell4,12, Uri Tabori1,3
1Program in Genetics and Genome Biology, The Hospital for Sick Children, Canada, 2Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Canada, 3The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Canada, 4Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, UK, 5Division of Hematology/Oncology, The Hospital for Sick Children, Canada, 6Division of Neurosurgery, The Hospital for Sick Children, Canada, 7The Familial Gastrointestinal Cancer Registry at the Zane Cohen Centre for Digestive Disease, Mount Sinai Hospital, Canada, 8Department of Biochemistry & Molecular Biology, Tulane Cancer Center, Tulane University, School of Medicine, USA, 9Children’s Brain Tumour Research Centre, University of Nottingham, UK, 10Department of Molecular Genetics, University of Toronto, Canada, 11Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada, 12Department of Haematology, University of Cambridge, UK, 13Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Canada
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
Comprehensive genomic profiling (CGP) of pediatric gliomas reveals a high frequency of clinically relevant genomic alterations (CRGA) associated with benefit from targeted therapy
Zachary R Chalmers*1, Siraj M Ali1, Garrett M Frampton1, Juliann Chmielecki1, Norma A Palma1, Julia A Elvin1, Adrienne Johnson1, Roman Yelensky1, Jeffery S Ross1,4, Phillip J Stephens1, Vincent A Miller1, Angela J Waanders2, John Crawford3
1Foundation Medicine Inc, USA, 2Children's Hospital of Philadelphia, USA, 3Rady Children's Hospital San Diego, USA, 4Albany Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Conditional inactivation of Smarcb1 in P0 permissive mouse cells generates rhabdoid tumors in the peripheral nervous system and in the brain
Jeremie Vitte*1, Fabrice Chareyre1, Anat Stemmer-Rachamimov2, Alexander Judkins3, Marco Giovannini1
1Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, USA, 2Molecular Neuro-Oncology and Pathology Department, Massachusetts General Hospital and Harvard Medical School, USA, 3Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, USA
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Daam2 promotes tumor proliferation and migration in glioblastoma
Wenyi Zhu*1, Hyun-Kyoung Lee1, Joseph Loturco3, Carrie Mohila2, Benjamin Deneen1
1Baylor College of Medicine, USA, 2Texas Children's Hospital, USA, 3University of Connecticut, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Decoding the cellular heterogeneity of pediatric high grade glioma
Kwanha Yu*1, Jeffrey Carlson1, CC John Lin1, Wendy Zhu1, Nabil Ahmed2, Xiao-nan Li2, Carrie Mohila2, Michelle Monje3, Akash J Patel2, Benjamin Deneen1
1Baylor College of Medicine, USA, 2Texas Children's Hospital, USA, 3Stanford University, USA
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Delta-24-RDG as an alternative therapeutic tool for pHGG/DIPG
Naiara Martinez-Velez*1, Enric Xipell1, Hong Jiang2, Cande Gómez-Manzano2, Juan Fueyo2, Marie-Pierre Junier3, Hervé Chneiweiss3, Elias El Habr3, Michelle Monje4, Oren Becher5, Marta M Alonso1
1Clinica Universidad de Navarra, Spain, 2MD Anderson Cancer Center, USA, 3Inserm, France, 4Stanford University, USA, 5Duke University School Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Detection of K27M mutant pediatric glioblastomas by immunohistochemistry
Sriram Venneti*1, Mariarita Santi2, Michelle Madden Felicella3, Dmitry Yarilin4, Joanna Phillips5, Lisa Sullivan2, Daniel Martinez2, Arie Perry5, Peter Lewis6, Craig Thompson4, Alexander Judkins7
1University of Michigan, USA, 2Children’s Hospital of Philadelphia, USA, 3Henry Ford Health System, USA, 4Memorial Sloan Kettering, USA, 5University of California, San Francisco, USA, 6University of Wisconsin-Madison, USA, 7Children’s Hospital Los Angeles, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Development of a novel gene targeting and clone screening platform to engineer common pediatric glioma mutations into model cell lines
Nathan Fons*1,2, Ranjini Sundaram2, Ranjit Bindra1,2
1Experimental Pathology, Yale University, USA, 2Therapeutic Radiology, Yale University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Differential splicing of pyruvate kinase regulates progenitor cell cycle and medulloblastoma tumorigenesis
Katherine Tech*, Tia Fish, Andrew Crowther, Andrey Tikunov, Jeffrey Macdonald, Timothy Gershon
University of North Carolina at Chapel Hill, USA
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Discovering the treatment refractory BTIC population in group 3 medulloblastoma
David Bakhshinyan*, Thusyanth Vijayakumar, Neha Garg, Branavan Manoranjan, Nicole McFarlane, Chitra Venugopal, Sheila Singh
McMaster University, Canada
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Disrupting the epigenetic modifier HMGA2 in DIPG and GBM inhibits tumor invasion, growth and tumorigenicity
Harpreet Kaur*, Marianne Hütt-Cabezas, Isabella Taylor, Melanie Weingart, Fausto Rodriguez, Charles Eberhart, Eric Raabe
The Johns Hopkins Hospital, USA
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Disruption of perivascular astrocytic foot processes characterizes MRI enhancement in pediatric brain tumors
Christopher Hong, Martin Piazza*, Winson Ho, Zhengping Zhuang
National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Dissecting the role of epigenetic modulators in Shh-driven medulloblastoma
Tara Dobson*1, Rong-Hua Tao1, Shavali Shaik1, Pete Taylor1, Rashieda Hatcher1, Ellen Busschers1, Soumen Khatua1, Stewart Goldman2, Rishi Lulla2, Veena Rajaram3, Tobey MacDonald4, Jason Fangusaro2, Vidya Gopalakrishnan1
1University of Texas MD Anderson Cancer Center, USA, 2Northwestern University, USA, 3University of Texas Southwestern Medical Center, USA, 4Emory University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Distinct brain lineage and stromal gene expression patterns in WNT, SHH, Group 3 and Group 4 molecular subgroups of pediatric medulloblastoma
Achal Achrol2, Tiffany Liu4, Hannes Vogel3, Steven Chang2, Michael Edwards2, Griffith Harsh2, Debashis Sahoo*1
1Department of Pediatrics, University of California San Diego School of Medicine, USA, 2Department of Neurosurgery, Stanford University Medical Center, USA, 3Department of Pathology (Neuropathology), Stanford University Medical Center, USA, 4Department of Medicine (Stanford Center for Biomedical Informatics Research), Stanford University Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
DLX homeobox genes regulate neuronal vs oligodendroglial cell fate decisions: potential relevance to pediatric glioneuronal tumors and high grade gliomas
Jamie Zagozewski1, Sara Japoni1, Qiang Jiang1, Frank van Landeghem1, Paolo Nozza2, Alessandro Raso2, David Eisenstat*1
1University of Alberta, Canada, 2Instituto Giannina Gaslini, Italy
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
DNA methylation in medulloblastoma and molecular diagnostics of brain tumors
Volker Hovestadt*1, David Capper2,5, Martin Sill3, Simone Picelli1, Wei Wang1, Paul A. Northcott4, Marcel Kool4, Marc Zapatka1, Bernhard Radlwimmer1, Andreas von Deimling2,5, Stefan M. Pfister4,6, Peter Lichter1, David T. W. Jones4
1Division of Molecular Genetics, German Cancer Research Center (DKFZ), Germany, 2CCU Neuropathology, German Cancer Research Center (DKFZ), Germany, 3Division of Biostatistics, German Cancer Research Center (DKFZ), Germany, 4Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 5Department of Neuropathology, Heidelberg University Hospital, Germany, 6Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Germany
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effectiveness of perfusion and diffusion imaging for grading pediatric brain tumors
Teresa Kelly*1,2, Melissa Prah2,3, Sachin Jogal1,2, Mohit Maheshwari1,2, Sean Lew1,2, Kathleen Schmainda2,3
1Children's Hospital of Wisconsin, USA, 2Medical College of Wisconsin, USA, 3Froedtert Hospital, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effects of everolimus on meningioma growth in patients with neurofibromatosis Type 2
Diana Osorio*, Alexander Filatov, Mari Hagiwara, Carole Mitchell, Jeffrey Wisoff, John Golfinos, J. Thomas Roland, Jeffrey Allen, Matthias Karajannis
NYU Langone Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effects of T-cell TGF-β signaling abrogation on survival in pediatric glioma
Joshua Breunig*, Moise Danielpour, Rachelle Levy, Marina Dutra-Clarke
Cedars-Sinai, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effects of TORC1/2 inhibitor MLN0128 alone and in combination with MEK inhibition in BRAF mutated glioma cells
Sabine Mueller*1, Rogier Dik1, Xiaodong Yang1, Ola Aleksandra1, Clay Gustafson1, Steve DuBois1, William Weiss1, Angela Waanders2, Adam Resnick2, Daphne Haas-Kogan1
1University of California San Francisco, USA, 2University of Pennsylvania Perelman School of Medicine, The Children’s Hospital of Philadelphia, USA
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Elucidation of pathogenesis in intracranial germ cell tumors based on a genome-wide methylation study
Shintaro Fukushima1, Satoshi Yamashita2, Hirokazu Takami1, Kohei Fukuoka1, Yoshitaka Narita3, Toshikazu Ushijima2, Masao Matsutani4, Ryo Nishikawa4, Koichi Ichimura*1, Intracranial Germ Cell Tumors Genome Analysis Consortium1
1Division of Brain Tumor Translational Research, National Cancer Center Research Institue, Japan, 2Division of Epigenomics, National Cancer Center Research Institue, Japan, 3Department of Neurosurgery and Neurooncology, National Cancer Center Hospital, Japan, 4Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Japan
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
ER stress inducing drugs downregulates MGMT and MPG sensitizing pediatric glioma cell lines to TMZ
Enric Xipell*1, Naiara Martinez-Vélez1, Marisol Gonzalez-Huarriz1, Arlet Acanda de la Rocha1, Chris Jones2, Marta M. Alonso1
1University Hospital of Navarra, Spain, 2The Institute of Cancer Research, UK
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Establishment and molecular characterization of patient-derived xenograft models of pediatric brain tumors
Sebastian Brabetz*1, Huriye Seker-Cin1, Susanne N. Gröbner1, Volker Hovestadt2, David T. W. Jones1, Paul A. Northcott1, Till Milde3,4, Jessica M. Rusert5, Kyle Pedro6, Karina Bloom6, Xiao-Nan Li7, Robert J. Wechsler-Reya5, James M. Olson6, Stefan M. Pfister1,4, Marcel Kool1
1Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 2Division of Molecular Genetics, German Cancer Research Center (DKFZ), Germany, 3CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Germany, 4Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany, 5Sanford-Burnham Medical Research Institute, USA, 6Fred Hutchinson Cancer Research Center and Seattle Children's Hospital, USA, 7Laboratory of Molecular Neuro-Oncology, Baylor College of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Evaluating the oncogenic potential of TSC1/2 mutations and efficacy of MTOR inhibitors in high risk pediatric medulloblastoma
Jacob Henderson*, Jacob Wagner, Monika Davare
Doernbecher Children's Hospital OHSU, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Expression of CRMP1 inhibits cell proliferation of medulloblastoma and is regulated by HMGA1
Ho-Keung Ng*1,2, Ka Wai Kay Li1,2, Yan Qi1, Xia Tian1, Yu Yao3, Liangfu Zhou3, Kin-Mang Lau1
1Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, 2Shenzhen Research Institute, The Chinese University of Hong Kong, China, 3Department of Neurosurgery, Huashan Hospital, Fudan University, Hong Kong
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Ezh2, a novel target in treatment of medulloblastoma
Brandon Ricke1, Kushal Shah1, Michael Salacz1, Paul Camarata1, Darren Lovick2, Warner Peng1, Roya Dolatkhah1, Zohreh Sanaat1, Kyle Kimura*1, Danse Bi1, Sarah Taylor1, Tuba Esfandyari1, Faris Farassati1
1The University of Kansas School of Medicine, USA, 2University of Missouri Kansas City School of Medicine-St Luke's Hospital, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Feasibility of vorinostat combined with isotretinoin and chemotherapy for young children with newly diagnosed embryonal brain tumors: A Pediatric Brain Tumor Consortium Study
Sarah Leary*1,4, Lindsay Kilburn2, J. Russell Geyer1,4, James M. Olson1,4, Tobey MacDonald8, David Ellison3, Mehmet Kocak3, Arzu Onar3, Ralph Ermoian6, Tina Young Poussaint7, James M. Boyett3, Larry Kun3, Maryam Fouladi3
1Seattle Children's, USA, 2Children's National Medical Center, USA, 3St. Jude Children's Research Hospital, USA, 4Fred Hutchinson Cancer Research Center, USA, 5Cincinnati Children's Hospital Medical Center, USA, 6University of Washington, USA, 7Dana Farber Cancer Institute, USA, 8Children's Healthcare of Atlanta, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Feedback activation of EGFR via PTPN9 leads to glioma escape from BRAFV600E targeted therapy
Tsun-Wen Yao*1, Jie Zhang1, Michael Prados1, William Weiss1,2, David James3,4, Theodore Nicolaides1,2
1Departments of Pediatrics, UCSF, USA, 2Departments of Neurological Surgery, UCSF, USA, 3Departments of Neurological Surgery, Northwestern University, USA, 4Developmental Therapeutics Institute, Northwestern University, USA
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Functional characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes
Lisa Liang*1, Christopher Aiken1, Robyn McClelland1, Ludivine Morrison1, Marc Remke2, Vijay Ramaswamy2, Marc Del Bigio1, Michael Taylor2, Tamra Werbowetski-Ogilvie1
1University of Manitoba, Canada, 2The Hospital for Sick Children, Canada
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Functional diversity and co-operativity of subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells 
Mara Vinci*1, Anna Burford1, Katy Taylor1, Valeria Molinari1, Sergey Popov1, Wendy Ingram2, Andrew Moore2, Michelle Monje3, Marta Alonso4, Jane Pears5, Natacha Entz-Werle6, Carmen de Torres7, Ofelia Cruz7, Jaume Mora7, Angel Montero Carcaboso7, Alan Mackay1, Chris Jones1
1Institute of Cancer Research, UK, 2Queensland Childrens Medical Research Institute, Australia, 3Stanford University, USA, 4University Hospital of Navarra, Spain, 5Our Lady's Children's Hospital, Ireland, 6CHRU Hautepierre, France, 7Hospital San Joan de Deu, Spain
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
Functionally-defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso1,15, Yujie Tang*2,15, Nathalene Truffaux3,15, Noah E. Berlow4,16, Lining Liu2,16, Marie-Anne Debily3,5, Michael J. Quist1, Lara Davis6, Elaine C. Huang6, Pamelyn J. Woo2, Anitha Ponnuswami2, Spenser Chen2, Tessa Johung2, Wenchao Sun2, Mari Kogiso7, Yuchen Du7, Qi Lin7, Yulun Huang7,8, Marianne Hutt-Cabezas9, Katherine E. Warren10, Ludivine Le Dret3, Paul S. Meltzer10, Hua Mao7, Martha Quezado10, Dannis G. van Vuurden11, Jinu Abraham6, Maryam Fouladi12, Matthew N. Svalina6, Nicholas Wang1, Cynthia Hawkins13, Eric Raabe9, Esther Hulleman11, Paul T. Spellman1, Xiao-Nan Li7, Charles Keller6, Ranadip Pal4, Jacques Grill3,14, Michelle Monje2
1Center for Spatial Systems Biomedicine Department of Molecular and Medical Genetics, Oregon Health & Science University, USA, 2Depts. of Neurology, Neurosurgery and Pediatrics, Stanford University, USA, 3Unité Mixte de Recherche du Centre National de la Recherche Scientifique 8203, Institut Gustave Roussy et Université Paris-Sud, France, 4Electrical and Computer Engineering, Texas Tech University, USA, 5Université d'Evry-Val d'Essone, France, 6Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Dept. of Pediatrics, Oregon Health & Science University, Portland, OR, USA; Children’s Cancer Therapy Development Institute, USA, 7Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, USA, 8Department of Neurosurgery, The First Affiliated Hospital of Soochow, China, 9Departments of Oncology and Pathology, Johns Hopkins University, USA, 10National Cancer Institute, USA, 11Department of Pediatric Oncology, Hematology and Neuro-Oncology Research Group Cancer Center Amsterdam, VU University Medical Center, The Netherlands, 12Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, USA, 13Dept. of Paediatric Laboratory Medicine, University of Toronto; Scientist, Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Canada, 14Departement de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, Université Paris-Sud, France, 15These authors contributed equally to this work, -, 16These authors contributed equally to this work, -
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
GBM-associated exosome-pulsed autologous DC vaccine (DC-Vex®) induces D-2 apoptotic-stage and bystander killing-effect in GBM of the mesenchymal type
John Giannios
Int Soc of Molecular and Genomic Medicine and Int Assoc of Perioperative Medicine and Nanosurgery, Greece
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Genetically engineered mouse models of choroid plexus tumors
Jun Wang*1, Diana Merino3, Brian Murphy2, Girish Dhall4, Erin Kiehna4, Alexander Judkins4, David Ellison2, Charles Eberhart5, Scott Vandenberg6, David Malkin3, Richard Gilbertson2, Martine Roussel2, Robert Wechsler-Reya1
1Sanford-Burnham Medical Research Institute, USA, 2St. Jude Children's Research Hospital, USA, 3The Hospital for Sick Children, Canada, 4Children's Hospital of Los Angeles, USA, 5Johns Hopkins University School of Medicine, USA, 6University of California, San Diego, USA
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Genome-wide copy number analysis, neuropathological classification and analysis of hedgehog activation: Histology reflects genetics and biology in medulloblastomas of young children
Elena Kapitza1, Dorota Denkhaus1, Anja zur Mühlen1, Stefan Rutkowski2, Torsten Pietsch*1
1Department of Neuropathology and Brain Tumor Reference Center, University of Bonn, Germany, 2Department of Pediatric Hematology and Oncology, University Clinics of Hamburg-Eppendorf, Germany
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
GSK-3 promotes proliferation during postnatal cerebellar development and may be targeted in medulloblastoma therapy
Jennifer Ocasio*, Timothy Gershon
University of North Carolina, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
H3.3-K27M is a negative prognostic marker in thalamic pediatric glioma
Scott Ryall*1,2, Pawel Buczkowicz1, Rahul Krishnatry1, Anthony Arnoldo1, Paul Steinbok3,4, Uri Tabori1,2, Cynthia Hawkins1,2
1Hospital for Sick Children, Canada, 2University of Toronto, Canada, 3BC Children's Hospital, Canada, 4University of British Columbia, Canada
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
HDAC and PI3K antagonists cooperate to inhibit growth of MYC-driven medulloblastoma
Kun-Wei Liu*1, Yanxin Pei1,2, Robert Wechsler-Reya1
1Sanford-Burnham Medical Research Institute, USA, 2Children’s National Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Heterogeneity of RelA protein expression in paediatric ependymoma
Tim Ritzmann*, Hazel Rogers, Jennifer Ward, Richard Grundy
Children's Brain Tumour Research Centre, The University of Nottingham, UK
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglial-like leptomeningeal tumors
Matthew J Schniederjan*1,2, Fausto J Rodriguez3, Theo Nicolaides4, Tarik Tihan4, Peter C Burger3, Arie Perry4
1Children's Healthcare of Atlanta, USA, 2Emory University School of Medicine, USA, 3Johns Hopkins University, USA, 4University of California San Francisco School of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Hypoxia pathway driven by HIF-1alpha are predominantly involved in pediatric high grade glioma and represent promising therapeutic targets
Christelle Lasthaus1, Marie Litzler1, Cyril Bour1, Dominique Guenot1, Natacha Entz-Werlé*1,2
1EA3430, University of Strasbourg, France, 2pediatric Oncology, France
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Identification of targetable mutations in rare pediatric brain tumors by clinical whole exome sequencing
Frank Y. Lin*, Abhishek Bavle, David Wheeler, Richard Gibbs, Sandi Lam, Jack Su, Murali Chintagumpala, Adekunle Adesina, Angshumoy Roy, Sharon E. Plon, D. Williams Parsons
Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
IDH1-mutated pituitary adenoma challenges traditional characterization of Maffucci syndrome
Christopher Hong*1, Shuyu Hao2, Jie Feng2, Chunzhang Yang1, Prashant Chittiboina1, Junting Zhang3, Zhengping Zhuang1
1National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch, USA, 2Beijing Tiantan Hospital, Capital Medical University, China, 3Beijing Neurosurgical Institute, Capital Medical University, China
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Immunologic targeting of medulloblastoma subtypes using developmentally regulated antigens
Christina Pham*1, Catherine Flores1, Yanxin Pei2, Robert Wechsler-Reya2, Duane Mitchell1
1University of Florida, USA, 2Sanford-Burnham Medical Research Institute, USA, 3Duke University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Immunotargeted-molecular-robotic-nanosurgery(ITMRN) eradicates GBM stem-cells with radiofrequency dielectric heating(RFDH) mediated via silver-immunonanobots linked with anti-CD133 MAbs
John Giannios
Int Soc of Molecular and Genomic Medicine and Int Assoc of Perioperative Medicine and Nanosurgery, Greece
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Impact of H3.3K27M mutation on cancer epigenome
Dong Fang, Zhiguo Zhang*
Mayo Clinic, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Impact of molecular sub-type and craniospinal irradiation (CSI) dose on relapse of medulloblastoma
Ange Wang*1, Sonia Partap1, Kristen Yeom1, Mesha Martinez2, Hannes Vogel1, Sarah Donaldson1, Paul Fisher1, Sebastien Perreault3, Yoon-Jae Cho1, Iris Gibbs1
1Stanford University School of Medicine/Lucille Packard Children's Hospital, USA, 2Temple University, USA, 3University of Montreal-CHU Sainte-Justine, Canada
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Implementation of next generation copy number and mutational analysis in routine neuropathology: molecular inversion profiling is a helpful tool in differential diagnostics and prognostification of pediatric brain tumors
Torsten Pietsch*1, Marco Gessi1, Anja zur Mühlen1, Evelyn Dörner1, Andy Last2, Padma Sundar2
1Department of Neuropathology, Brain Tumor Reference Center, University of Bonn, Germany, 2Affymetrix, USA
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Induced cisplatin resistance in medulloblastomas
Michael Feldman*1,2, Winson Ho1, John Heiss1, Matthew Hall3, Zhenping Zhuang1
1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, USA, 2University of Rochester School of Medicine and Dentistry, USA, 3Laboratory of Cell Biology, National Cancer Institute, NIH, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Infantile glioblastoma with sarcomatous histology driven by ETV6:NTRK3 fusions are sensitive to Trk inhibition by PHA-848125
Diana Carvalho*1, Katy Taylor1, Anna Burford1, Ilona Nowak1, Alan Mackay1, Mara Vinci1, Lynn Bjerke1, Valeria Molinari1, Meera Nandhabalan1, Wendy Ingram2, Alexa Jury1, Rachael Natrajan1, David Jones3, Stefan Pfister3, Ludmila Shats4, Andrew Moore2, Thomas Jacques5, Sergey Popov1, Chris Jones1
1Institute of Cancer Research, UK, 2Queensland Childrens Medical Research Institute, Australia, 3DKFZ, Germany, 4Hospital #31, Russia, 5Great Ormond Street Hospital, UK
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Inflammation driver, NF-kB, is associated with poor outcome Group A ependymoma and regulates a key immune suppressive signaling pathway involved in the tumor microenvironment
Andrea Griesinger*1,2, Andrew Donson1,2, Jean Mulcahy Levy1,2, Vladimir Amani1,2, Diane Birks1,2, Rajeev Vibhakar1,2, Michael Handler1,2, Nicholas Foreman1,2
1University of Colorado Denver, Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Inhibition of AKT signaling and tumor growth by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cell line in vitro and in nude mice xenografts
Cheppail Ramachandran*1,2, Gilda Portalatin1, Karl-Werner Quirin3, Enrique Escalon1, Ziad Khatib1, Steven Melnick1,2
1Miami Children's Hospital, USA, 2Dharma Biomedical LLC, USA, 33Flavex Naturextrakte GmbH, Germany
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Inhibition of epigenetic regulation as a therapy for pediatric high grade glioma
Stephen Dombrowski*1, Thamara Abou-Antoun2, Stephen Mack3, Xiao-Nan Li4, Peter Houghton5, Darell Bigner6, Jeremy Rich3, Violette Recinos1
1Department of Neurological Surgery, Pediatric Neurosurgical Oncology, Cleveland Clinic, USA, 2Department of Natural Sciences, Lebanese American University, Lebanon, 3Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, USA, 4Laboratory of Molecular Neuro-Oncology, Texas Children's Hospital, Baylor College of Medicine, USA, 5Nationwide Children's Hospital, USA, 6Division of Neurosurgery, Department of Surgery, Duke University Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors
Marc Remke*1, Florence Cavalli1, A. Sorana Morrissy1, Vijay Ramaswamy1, David Jones2, Roger Packer3, Eric Bouffet1, Gary Bader4, Stefan Pfister2, Nada Jabado5, Marco Marra6, Michael Taylor1
1Hospital for Sick Children, Canada, 2German Cancer Research Center (DKFZ), Germany, 3Children’s National Medical Center, USA, 4University of Toronto, Canada, 5McGill University and the McGill University Health Center Research Institute, Canada, 6Michael Smith Genome Sciences Centre, BC Cancer Agency, Canada
Thursday, May 7:  Session 7 - Medulloblastoma 1  -  4:40pm - 5:10pm
Integrative molecular meta-analysis of 700 pediatric high grade glioma and DIPG defines widespread inter- and intra-tumoral heterogeneity
Alan Mackay*1, Mara Vinci1, Anna Burford1, Lynn Bjerke1, Katy Taylor1, Meera Nandhabalan1, Lynley Marshall1, Valeria Molinari1, Sergey Popov1, Wendy Ingram2, Andrew Moore2, Saoussen Trabelsi3, Dorra Hmida3, Kun Mu4, Lucas Bidinotto5, Rui Reis5, HK Ng6, Andre von Bueren7, Michael Baudis8, Chris Jones1
1Institute of Cancer Research, UK, 2Queensland Childrens Medical research Institute, Australia, 3CHU Farhat HACHED, Tunisia, 4Qilu Hospital, China, 5Barretos Cancer Hospital, Brazil, 6Chinese University of Hong Kong, Hong Kong, 7University of Goettingen, Germany, 8University of Zurich, Switzerland
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Intracranial nongerminomatous germ cell tumors: treatment strategies and outcomes
Brandon Imber*1, Steve Braunstein1, Anuradha Banerjee3, Tarik Tihan4, Andrew Bollen4, Daphne Haas-Kogan1,5, Sabine Mueller2,3
1Department of Radiation Oncology, University of California, San Francisco, USA, 2Department of Neurology, Division of Child Neurology, University of California, San Francisco, USA, 3Department of Pediatrics, University of California, San Francisco, USA, 4Department of Pathology, University of California, San Francisco, USA, 5Department of Neurosurgery, University of California, San Francisco, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
LB100, a novel protein phosphatase 2A inhibitor, enhances cisplatin and radiation mediated cytotoxicity and overcome cisplatin resistance in-vitro
Sze Chun Winson Ho*, Michael Feldman, Dragan Maric, John Heiss, Zhengping Zhuang
National Institute of Health, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
LIN28 and MYC expressing pediatric glioblastomas are sensitive to inhibitors of glutamine metabolism
Isabella Taylor*, Sama Ahsan, Melanie Weingart, Charles Eberhart, Eric Raabe
Johns Hopkins Hospital, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Measuring tumor metabolism in diffuse intrinsic pontine gliomas (DIPG) using hyperpolarized carbon-13 MR spectroscopic imaging
Ilwoo Park*1, Rintaro Hashizume2, Xiaodong Yang3, Peder Larson1, C. David James2, Daniel Vigneron1, Sabine Mueller3,4, Sarah Nelson1,5
1Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco,, USA, 2Neurological Surgery and Biochemistry and Molecular Genetics, USA, 3Brain Tumor Research Center, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, USA, 4Department of Neurology, University of California, San Francisco, USA, 5Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco,, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Medulloblastoma subtypes specify inter-tumoral vascular blood brain barrier heterogeneity
Timothy Phoenix*1, Deanna Patmore1, Scott Boop1, Megan Jacus1, Yogesh Patel1, Lilian Goumnerova2, Sebastien Perreault3, Elizabeth Wadhwa3, Yoon-Jae Cho3, Clinton Stewart1, Richard Gilbertson1
1St. Jude Children's Research Hospital, USA, 2Boston Children's Hospital, USA, 3Stanford University, USA
Thursday, May 7:  Session 7 - Medulloblastoma 1  -  4:40pm - 5:10pm
Metachronous supratentorial intracranial malignant tumors in two pediatric patients with infratentorial medulloblastoma on hormone therapy
Augustus Perez*, James Shiflett, Betty Herrington
University of MIssissippi Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
MGMT promoter methylation status and miRNA-181 family expression as prognostic markers in glioblastoma patients
Li Bie*, Cong Hua, Gang Zhao, Yuanqian Li
The First Hospital of Jilin University, China
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
MicroRNA expression patterns in tissue and cerebrospinal fluid aid in molecular classification of pediatric medulloblastoma
Rishi Lulla*1, Joseph Laskowski1, Yingtao Bi2, Stewart Goldman1, Jason Fangusaro1, Vidya Gopalakrishnan3
1Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, USA, 2in Preventive Medicine-Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, USA, 3Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center,, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Modeling pediatric GBM using neural stem cell-derived tumors with divergent behavior
Olle R Lindberg*, Andrew McKinney, Jane R Engler, Joanna J Phillips
University of California, San Francisco (UCSF), USA
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Molecular classification of ependymal tumors across all CNS compartments, histopathological grades and age groups
Kristian W. Pajtler1, Hendrik Witt1,2, Martin Sill1, David Jones1, Volker Hovestadt1, Pascal Johann1, Juri Reimand3, Peter Lichter1,6, Michael D. Taylor4, Richard Gilbertson5, David W. Ellison5, Kenneth Aldape3, Andrey Korshunov1,2, Stefan M. Pfister1,2, Marcel Kool*1
1German Cancer Research Center DKFZ, Germany, 2University Hospital Heidelberg, Germany, 3University of Toronto, Canada, 4Hospital for Sick Children, Canada, 5St Jude Children's Research Hospital, USA, 6German Cancer Consortium DKTK, Germany
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Molecular classification of ependymomas in  a Japanese cohort
Kohei Fukuoka*1,8, Shintaro Fukushima1,8, Satoshi Yamashita2, Tomoko Shofuda3,8, Taishi Nakamura1,8, Kai Yamasaki1,8, Hirokazu Takami1,8, Yuko Matsushita1,8, Toshikazu Ushijima2, Yoshitaka Narita4,8, Yonehiro Kanemura3,8, Mami Yamasaki5,8, Soichiro Shibui4,8, Hajime Arai6,8, Ryo Nishikawa7,8, Koichi Ichimura1,8
1Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Japan, 2Division of Epigenetics, National Cancer Center Research Institute, Japan, 3Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Japan, 4Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Japan, 5Department of Pediatric Neurosurgery, Takatsuki General Hospital, Japan, 6Department of Neurosurgery, Juntendo University, Japan, 7Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Japan, 8Japan Pediatric Molecular Neuro-Oncology Group (JPMNG), Japan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Molecular engineering of amplified tumor RNA-pulsed dendritic cells in adoptive cellular therapy targeting medulloblastoma and glioblastoma
Oleg Yegorov*, Jeffery Drake, Duane Mitchell
University of Florida, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Molecular (re-)classification of CNS-primitive neuroectodermal tumors
Marcel Kool*1, Dominik Sturm1, Volker Hovestadt1, David Jones1, Paul Northcott1, Peter Lichter1, Andrey Korshunov1,2, Stefan Pfister1,2
1German Cancer Research center DKFZ, Germany, 2University Hospital Heidelberg, Germany
Thursday, May 7:  Session 7 - Medulloblastoma 1  -  4:40pm - 5:10pm
Molecular subgroups of medulloblastoma identification using non-invasive magnetic resonance spectroscopy
Ashley Margol*1,2, Stefan Bluml1,2, Richard Sposto1,2, Rebekah Kennedy1, Nathan Robison1,2, Marzieh Vali1, Long Hung1, Sakunthala Muthugounder1, Jonathan Finlay3, Anat Erdreich-Epstein1,2, Floyd Gilles1,2, Alexander Judkins1,2, Mark Krieger1,2, Girish Dhall1,2, Marvin Nelson1,2, Shahab Asgharzadeh1,2
1Children's Hospital Los Angeles, USA, 2University of Southern California, USA, 3Nationwide Children's Hospital, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Mosaic genetic progression models of low grade pediatric brain tumors reveal unique features of tumor evolution
C. Danielle Antonuk, Rachelle Levy, Jessica Molina, Moise Danielpour, Aslam Akhtar, Joshua Breunig*
Cedars-Sinai, USA
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Multicentric primary central nervous system diffuse large b cell lymphoma in an inmunocompetent adolescent, case report
Jose Leon*, Rocio Cardenas, Marta Zapata, Liliana Velasco
Instituto Nacional de Pediatria, Mexico
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Multispecific CAR T cells for the treatment of high grade glioma
Kevin Bielamowicz*, Kristen Fousek, Tiara Byrd, Kevin Chow, Zhongzhen Yi, Simone Krebs, Gianpietro Dotti, Stephen Gottschalk, Meena Hegde, Nabil Ahmed
Baylor College of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Nanoparticle siRNA delivery vehicles inhibit DNA repair and sensitize pediatric brain tumor cells to radiation therapy
Forrest Kievit*, Zachary Stephen, Kui Wang, Christopher Dayringer, John Silber, Richard Ellenbogen, Miqin Zhang
University of Washington, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Neural derivatives from human embryonic stem cells: a cellular system to study the role of Otx2 in medulloblastoma progression.
Ravinder Kaur*1, Christopher Aiken1, Ludivine Coudiere Morrison1, Radhika Rao2, Marc Del Bigio3, Shravanti Rampalli2, Tamra Werbowetski-Ogilvie1
1Regenerative Medicine Program, Department of Biochemistry and Medical Genetics and Physiology, University of Manitoba, Canada, 2Centre for Inflammation and Tissue Homeostasis, Institute of Stem Cell Biology and Regenerative Medicine, NCBS-TIFR Campus, India, 3Department of Pathology, University of Manitoba, Canada
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Neural stem cell-mediated enzyme/prodrug therapy for medulloblastoma
Margarita Gutova1, Diana Oganesyan1, Silvia Tacheva Grigorova2, Yanxin Pei2, David Shahmanyan*1, Zhongqi Li1, Michael Barish1, Karen Aboody1, Robert Wechsler-Reya2
1City of Hope, USA, 2Sanford Burnham Research Institute, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Neuronal activity-regulated secretion of neuroligin-3 promotes glioma growth
Humsa Venkatesh1, Tessa Johung1, Viola Caretti1, Alyssa Noll1, Hannes Vogel1, Markus Bredel2, Parag Mallick1, Michelle Monje*1
1Stanford University, USA, 2University of Alabama, USA
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
NK cell immunotherapy for pediatric brain tumors: overcoming resistance to expand therapeutic success
William Brugmann*1, Alvaro Laureano4, Keith Michel1, Rong-Hua Tao1, Bridget Kennis1, Srinivas Somanchi1, Cecele Denman1, King Ching Ho3, Lucia Silla4, Harjeet Singh1, Helen Huls1, David Sandberg2, Dean Lee1, Jim Bankson1, Annie Huang3, Laurence Cooper1, Vidya Gopalakrishnan1
1University of Texas M.D. Anderson Cancer Center, USA, 2University of Texas Health Science Center, USA, 3Hospital for Sick Children, Canada, 4Centro de Tecnologia e Terapia Celular do Hospital de Clínicas de Porto Alegre, Brazil
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Notch and Shh signaling pathways converge on the primary cilium to promote choroid plexus tumor initiation from epithelial progenitors
Haotian Zhao*1,2, Li Li1, Katie Picotte1, Jun Wang3, Robert Wechsler-Reya3, Jasmin Ohli4, Ulrich Schüller4
1Sanford Research, USA, 2Sanford School of Medicine, University of South Dakota, USA, 3Sanford-Burnham Medical Research Institute, USA, 4Ludwig-Maximilans University, Germany
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Notch signaling activation in pediatric low-grade astrocytoma
William D. Brandt1, Karisa C. Schreck1, Eli E. Bar2, Isabella Taylor1, Luigi Marchionni1, Eric Raabe1, Charles G. Eberhart1, Fausto J. Rodriguez*1
1Johns Hopkins University, USA, 2Case Western Reserve University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Notch1 promotes MYC medulloblastoma metastasis, initiation and maintenance
Suzana Kahn*1,2, Ryan Nitta1, Kevin Wang3, Sharareh Gholamin1,2, Tej Azad1, Michael Zhang1, Yoon-Jae Cho1, Michael Taylor3, Siddhartha Mitra1,2, Irving Weissman2, Samuel Cheshier1
1Neurosurgery Department, Stanford University, USA, 2Institute for Stem Cell Biology and Regenerative Medicine, USA, 3The Hospital for Sick Children, Canada
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Novel candidate oncogenic drivers in pineoblastoma
Matija Snuderl*1, Kasthuri Kannan1, Olga Aminova1, Igor Dolgalev1, Adriana Heguy1, Arline Faustin1, David Zagzag1, Sharon Gardner1, Jeffrey Allen1, Jeffrey Wisoff1, David Capper2, Volker Hovestadt2, Sama Ahsan3, Charles Eberhart3, Stefan Pfister2, David Jones2, Matthias Karajannis3
1NYU Langone Medical Center, USA, 2German Cancer Research Center, Germany, 3Johns Hopkins University, USA
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
OKN-007: a novel compound for treating pediatric glioblastoma
Samantha Mallory*1,2, Rene McNall-Knapp1, Patricia Coutinho DeSouza2,3, Nataliya Smith2, Debra Saunders2, Kar-Ming Fung1, Rheal Towner1
1University of Oklahoma Health Science Center, USA, 2Oklahoma Medical Research Foundation, USA, 3Oklahoma State University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Oncolytic picornavirus SVV-001 prolongs animal survival in a patient tumor-derived orthotopic xenograft mouse model of Group 3 supratentorial primitive neuroectodermal tumor
Zhigang Liu2,1, Lin Qi1, Xiu Mei Zhao1, Yulun Huang1, Mari Kogiso1, Yuchen Du1, Holly Lindsay1, Patricia Baxter1, Jack Su1, Adekunle Adesina1, Murali Chintagumpala1, Xiao-Nan Li*1
1Texas Children's Hospital, Baylor College of Medicine, USA, 2Diana Helis Henry Medical Research Foundation, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Paradoxical genetic and epidemiologic relationships between cancer and autism
Rohini Singh*, Benjamin Darbro, Alexander Bassuk
University of Iowa, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pathway analysis of a human neural stem cell model of aggressive medulloblastoma reveals CDK inhibition as a potential therapeutic modality
Allison Hanaford*1, Tenley Archer2, Pablo Tamayo3, Scott Pomeroy2,3, Charles Eberhart1, Eric Raabe1,4
1Johns Hopkins School of Medicine, USA, 2Boston Children's Hospital, USA, 3Eli and Edythe Broad Institute of MIT and Harvard University, USA, 4Johns Hopkins Hospital, USA
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Pediatric anaplastic meningioma: a case report successfully treated with combined chemotherapy for soft tissue sarcomas and radiotherapy.
Maurizio Lucchesi*1, Sabrina Becciani1, Anna Maria Buccoliero2, Alessia Stival1, Ludovica Facchini1, Silvia Farina1, Maurizio de Martino1, Iacopo Sardi1
1Neuro-oncology Unit, Department of Paediatric Medicine, Meyer Children's University Hospital, Italy, 2Pathology Unit, Meyer Children's University Hospital, Italy
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pediatric grade II glioma molecular screening in adolescents and young adults
Irene Ollivier1,2, Christelle Lasthaus1, Marie Litzler1, Dominique Guenot1, Natacha Entz-Werlé*1,3
1EA3430, University of Strasbourg, France, 2Neurosurgery, France, 3pediatric Oncology, France
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Personalized targeted therapy in refractory or relapsed cancer in childhood (Triceps Study)
Sophie DUMOUCEL*, Michel DUVAL, Monia MARZOUKI, Henrique BITTENCOURT, Yvan SAMSON, Sonia CELLOT, Georges-Etienne RIVARD, Pierre TEIRA, Anne-Sophie CARRET, Jasmine HEALY, Dorothee DAL SOGLIO, Natacha PATEY, Nelson PICHE, Thomas SONTAG, Sylvie LANGLOIS, Mathieu LAJOIE, Daniel SINNETT
CHU Ste Justine, Canada
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pharmacological inhibition of MRK/ZAK kinase for the treatment of medulloblastoma
Rosamaria Ruggieri*1, Daniel Markowitz1, Caitlin Powell1, Nhan Tran2, Magimairajan Vanan3, Mingzu He1, Yousef Al Abed1, Marc Symons1
1The Feinstein Institute, USA, 2Translational Genomics Research Institute, USA, 3University of Manitoba, Canada
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pharmacological modulation of blood-brain barrier: a novel therapeutic approach to refractory CNS tumors
Sabrina Becciani1, Martina Da Ros*1, Anna Lisa Iorio1, Laura Giunti1, Alessia Stival1, Maurizio Lucchesi1, Maura Massimino2, Maurizio de Martino1, Iacopo Sardi1
1Neuro-oncology Unit, Department of Paediatric Medicine, Anna Meyer Children's University Hospital, Italy, 2Department of Paediatrics, IRCCS Foundation, National Cancer Institute, Italy
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
PID1 is a chemotherapy sensitizer and candidate tumor suppressor in medulloblastoma
Jingying Xu1, Xiuhai Ren1, Gregory M Shackleford1, Rex Moats1,2, Anat Erdreich-Epstein*1,2
1Children's Hospital Los Angeles, USA, 2University of Southern California, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
PLK1 as a potential therapeutic target for DIPG
Vladimir Amani*1,2, Sujatha Venkataraman1,2, Eric Prince1,2, Diane Birks1,2, Ilango Balakrishnan1,2, Andrew Donson1,2, Andrea Griesinger1,2, Peter Harris1,2, Nicholas Foreman1,2, Rajeev Vibhakar1,2
1University of Colorado Anschutz Medical Campus, USA, 2The Children’s Hospital Colorado, USA
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Posterior fossa ependymoma subgroups have distinct therapeutic and prognostic implications
Vijay Ramaswamy*, Stephen Mack, Michael Taylor, For the GENE consortium
Hospital for Sick Children, Canada
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Post-translational regulation of Atoh1: from cerebellar development to medulloblastoma formation
Sara Maria Cigna**1, Antoine Forget*1, Laure Bihannic1, Marc Remke2, Sandrine Humbert1, Michael D. Taylor2, Anna Lasorella3, Olivier Ayrault1
1Institut Curie, France, 2Hospital for Sick Children, University of Toronto, Canada, 3Institute for Cancer Genetics, Columbia University Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Preliminary results of a feasibility pilot study of “Gempox” (gemcitabine, oxaliplatin, and paclitaxel) in pediatric and adult patients with refractory or recurrent central nervous system (CNS) germ cell tumors (GCT): the International CNS GCT Consortium Trial, CNS GCT- 4
Jonathan Finlay*1, Kelly Haley2, Girish Dhall2, Diana Osorio1, Sharon Gardner3, Jeffrey Allen3, Jeffrey Leonard1
1Nationwide Children's Hospital and The Ohio State University, USA, 2Children's Hospital Los Angeles, USA, 3The Stephen D. Hassenfeld Children's Cancer Center, New York University, USA
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Primary central nervous system melanocytic lesions in childhood: experience at National Institute of Pediatrics in Mexico
Yahiel Osorio-Alamillo*1, Marta Zapata-Tarres1, Ana Niembro1, Rodolfo Rodriguez-Jurado2, Pedro Pasquel -García2, Mauricio Rojas2, Rolando Jimenez-Guerra3, Leticia Munive4, Patricia Herrera4
1Instituto Nacional de Pediatria Oncology Department, Mexico, 2Instituto Nacional de Pediatria Pathology Department, Mexico, 3Instituto Nacional de Pediatria Neurosurgery Department, Mexico, 4Instituto Nacional de Pediatría Neurology Department, Mexico
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Primary central nervous system non hodgkin lymphoma in a pediatric patient without immunodeficiency related. case report and literature review
Marco R. Aguilar-Ortiz*, Rocío Cardenas-Cardós, Liliana Velasco-Hidalgo, Pedro-Mario Pasquel-García-Vázquez, Roberto Rivera-Luna, Alfonso Marhx-Bracho
National Institute of Pediatrics (INP), Mexico
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Primary Ewing sarcoma of the scalp with apparent epidural extension: case illustration
William Gump*1,3, Robert Debski1, Matthew Thompson1, Kanyalakshmi Ayyanar1,2
1Kosair Children's Hospital, USA, 2University of Louisville School of Medicine, USA, 3Norton Neuroscience Institute, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Prognostic impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in medulloblastoma
Akihide Kondo*, Tomoko Kurimoto, Sachi Sakaguchi, Hajime Arai
Juntendo University, Japan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Radiation therapy is associated with increased late mortality in long-term adult survivors of childhood low grade glioma: A population based study
Rahul Krishnatry*1,2, Nataliya Zhukova1, Ana Guerreiro Stucklin1, Jason Pole8, Matthew Mistry1, Vijay Ramaswamy1, Ute Bartels1, Annie Huang1, Normand Laperriere1,2, Peter Dirks1, Shayna Zelcer3, Mariana Silva4, Donna L Johnston5, Katrin Scheinemann6, Cynthia Hawkins1, Pratiti Bandopadhayay7, Mark W Kieran7, Peter E Manley7, Eric Bouffet1, Uri Tabori1
1The Hospital for Sick children, Canada, 2Princess Margret Hospital, Canada, 3London Health Sciences Centre, Canada, 4Kingston General Hospital, Canada, 5CHEO Research Institute, Canada, 6McMaster Children's Hospital, Canada, 7Dana-Farber Cancer Institute, USA, 8Pediatric Oncology Group of Ontario, Canada
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
RalA in biology and therapy of MPNST in correlation to cancer stem cells
Kaoru Terai1, Emma Borrego-Diaz1, Darren Lovick2, Michael Salacz1, Adel Rezaei Moghadam1, Zohreh Sanaat1, Roya Dolatkhah1, Elham Patrad1, Mojtaba Amani1, Warner Peng1, Tuba Esfandyari1, Faris Farassati*1
1The University of Kansas Medical School, USA, 2The University of Missouri Kansas City-School of Medicine-St Luke's Hospital, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Regulation of medulloblastoma formation by Gfi1 and Gfi1b
Catherine Lee*1,2, Paul Northcott3, Thomas Zichner4, Jan Korbel4, Stefan Pfister3, Robert Wechsler-Reya1
1Sanford Burnham Medical Research Institute (SBMRI), USA, 2University of California, San Diego (UCSD), USA, 3German Cancer Research Center (DKFZ), Germany, 4European Molecular Biology Laboratory (EMBL), Germany
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
RNA nanoparticle vaccines re-program host immunity in favor of enhanced effector responses against intracranial malignancies
Elias Sayour1,2, Gabriel De Leon1,2, Christina Pham1,2, Catherine Flores1, Luis Sanchez-Perez2, Duane Mitchell*1
1University of Florida, USA, 2Duke University, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Role of mTOR signalling pathway in the pathogenesis of subependymal giant cell astrocytomas
Mehar Sharma*, Kalpana Kumari, Aanchal Kakkar, Chitra Sarkar, Vaishali Suri, Sarat Chandra
All India Institute of Medical Sciences, India
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Serial metabolism of diffuse intrinsic pontine glioma treated with peptide based vaccine therapy
Ashok Panigrahy*1,2, Brenda Kurland1, Rafael Ceschin1, Shira Abberbock1, Hideho Okada3, Regina Jakacki1, Ian Pollack1, Stefan Bluml2
1Childrens Hospital of Pittsburgh, USA, 2Childrens Hospital of Los Angeles, USA, 3UCSF, USA
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
SILAC based quantitative proteomics of MYC-amplified medulloblastoma
Jerome Staal, Ling San Lau, Huizhen Zhang, Yetrib Hathout, Kristy Brown, Brian Rood*
Children's National Medical Center, USA
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
Sonic hedgehog induces YB-1 in a YAP-dependent manner to regulate Igf2 expression and proliferation in cerebellar granule neuron progenitors and medulloblastoma cells
Abhinav Dey*1, Mélanie Robitaille2, Marc Remke3, Caroline Maier1, Anshu Malhotra1, Alex Gregorieff4, Jeffrey Wrana4, Michael Taylor3, Stéphane Angers2, Anna Kenney1
1Emory University, USA, 2University of Toronto, Canada, 3Hospital for Sick Children, Canada, 4Mount Sinai Hospital, Canada
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
SOX9 as a down-stream target in RAS/MEK-driven pediatric glioma
Hanna Sabelstrom*1, Rahul Jandial2, Ksenya Shchors1,5, Selma Masic1, Allen Ho3, Scott Vandenberg4, Theodore P. Nicolaides1, Kim Nguyen1, Stanislava Yakovenko1, Michael D. Prados1, C. David James1, Mitchel S. Berger1, Gerard I. Evan1, Evan Y. Snyder3, William A. Weiss1, Anders I. Persson1
1University of California, San Francisco, USA, 2City of Hope Cancer Center & Beckman Research Institute, USA, 3Sanford-Burnham Institute for Medical Research, USA, 4University of California, San Diego, USA, 5Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Study of epigenetic deregulation of a novel deubiquitylase in medulloblastoma
Rashieda Hatcher*1, Chandra Das1, Jason Fangusaro2, Veena Rajaram3, Rishi Lulla2, Stewart Goldman2, Soumen Khatua1, Gianluca Sbardella4, Vidya Gopalakrishnan1
1Children's Cancer Hospital and UT MD Anderson Cancer Center, USA, 2Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, USA, 3Children's Hospital and UT Southwestern Medical Center, USA, 4University of Salerno, Italy
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Successful treatment of ATRT patients without adjuvant radiation: a multi institutional Canadian experience
Dennis Ku*1, Lucie Lafay-Cousin3, Chris Fryer2, Juliette Hukin2, Doug Strother3, Annie Huang1, Eric Bouffet1
1The Hospital for Sick Children, Canada, 2BC Children Hospital, Canada, 3Alberta Children's Hospital, Canada
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Targeted combinatorial approach for treatment of pediatric low grade gliomas in the context of BRAFV600E and KIAA1549:BRAF mutations
Aleksandra K. Olow*1, Sabine Mueller1, Xiaodong Yang1, Rintaro Hashizume2, Justin Meyerowitz1, William Weiss1, Adam C. Resnick3, Angela J. Waanders3, Mitchel S. Berger1, Nalin Gupta1, C. David James2, Daphne A. Haas-Kogan1
1University of California, USA, 2Northwestern University Feinberg School of Medicine, USA, 3The Children's Hospital of Philadelphia, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Targeted inhbition of histone demethylase activity for the treatment of pediatric brainstem gliomas
Noemi Ander2, Robin Lerner2, Xi Huang2, Maxwell Tom2, Vy Ngo2, David Solomon1,3, Sabine Mueller2, Pamela Paris2, Zhiguo Zhang4, Nalin Gupta2, Todd Waldman3, Stewart Goldman1, David James1, Rintaro Hashizume*1
1Northwestern University, USA, 2University of California San Francisco, USA, 3Georgetown University School of Medicine, USA, 4Mayo Clinic, USA
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Targeted next generation sequencing in malignant supratentorial pediatric brain tumors reveals actionable mutations
Bonnie Cole1, Colin Pritchard2, Maia Anderson1, Sarah Leary*1,3
1Seattle Children's, USA, 2University of Washington, USA, 3Fred Hutchinson Cancer Research Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Targeting medulloblastoma with a new small-molecule drug that inhibits MYC mediated translation
Bronwen Foreman*, Irina Alimova, Peter Harris, Ilango Balakrishnan, Eric Prince, Nicholas Foreman, Rajeev Vibhakar, Sujatha Venkataraman
University of Colorado, Anschutz Medical Campus, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Targeting mTOR downstream of LIN28 in Atypical Teratoid Rhabdoid Tumors promotes apoptosis and suppresses tumorigenicity
Jeffrey Rubens*, Antoinette Price, Charles Eberhart, Eric Raabe
Johns Hopkins Hospital, USA
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Targeting Myc driven transcriptional output in atypical teratoid rhabdoid tumor
Irina Alimova*, Sujatha Venkataraman, Angela Pierce, Andrea Greisinger, Diane Birks, Ilango Balakrishnan, Nicholas Foreman, Rajeev Vibhakar
University of Colorado SOM, USA
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Tenascin-C: A novel therapeutic target in pediatric brainstem glioma
Amanda Saratsis*1,2, Madhuri Kambhampati3, Jordan Hall3, Mojca Stampar3, Guifa Xi2, Eric Raabe4, Roger Packer3, Javad Nazarian3
1Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 2Northwestern University Feinberg School of Medicine, USA, 3Children's National Medical Center, USA, 4Johns Hopkins University School of Medicine, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The anti-apoptotic protein ARC is over-expressed in malignant glioma and correlates with patient outcome
Anne Kankean*, Maria Tsoli, Joanna Tsang, Arjanna Chitranjan, Sanaz Maleki, Kerrie McDonald, David Ziegler
University of New South Wales, Australia
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The critical role of Olig2-expressing progenitors in the initiation of G-protein mediated Sonic Hedgehog-driven medulloblastoma
Xuelian Lu, Richard Lu*
Cincinnati Children's Hospital Medical Center, USA
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
The eEF2 kinase, a mediator of medulloblastoma adaptation to metabolic stress, supports fatty acid oxidation
Gabriel Leprivier*1, Raffaele Teperino2, Anders Kristensen1, Marc Remke3, Stefan Pfister4, Michael D. Taylor5, J. Andrew Pospisilik2, Poul H. Sorensen1
1British Columbia Cancer Research Centre and University of British Columbia, Canada, 2Max Planck Institute, Germany, 3University Hospital Düsseldorf, Germany, 4German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Germany, 5The Arthur and Sonia Labatt Brain Tumor Research Centre and University of Toronto, Canada
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
The effect of regadenoson-induced transient disruption of the blood brain barrier on temozolomide delivery to rat brain parenchyma
Sadhana Jackson*, Nicole Anders, Antonella Mangraviti, Henry Brem, Betty Tyler, Michelle Rudek, Stuart Grossman
Johns Hopkins, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The Hippo pathway activity in AT/RT
Mario Suzuki*, Akihide Kondo, Ikuko Ogino, Hajime Arai
Department of Neurosurgery, Juntendo University School of Medicine, Japan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The histone deacetylase inhibitor PCI-24781 shows antiproliferative, pro-apoptotic and radiosensitizing effects on pediatric glioblastoma cell-lines
Pamela Viani Andrade, Augusto Faria Andrade, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera*
Faculdade de Medicina de Ribeirão Preto, USP., Brazil
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Therapeutic targeting of INI1 deficiency in pediatric ATRT: a pre-clinical study utilizing patient derived orthotopic xenograft (PDOX) models
Holly Lindsay*1, Mari Kogiso1, Lin Qi1, Jeffrey Murray2, Laszlo Perlaky1, Jack Su1, Patricia Baxter1, Adekunle Adesina1, Donald Parsons1, Murali Chintagumpala1, Xiao-Nan Li1
1Baylor College of Medicine, USA, 2Cook Children's Hospital, USA
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Trilexium inhibits the expression of t-NOX and is a novel, potentially potent therapy for Diffuse Intrinsic Pontine Gliomas
Anne Kankean*1, Anahid Ehteda1, Arjanna Chitranjan1, Maria Tsoli1, Eleanor Ager2, David Ziegler1
1University of New South Wales, Australia, 2Novogen, Australia
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Tumor location remodels transcriptomic profiles in a pediatric medulloblastoma xenograft
Gregory Friedman*1, Li Nan1, Blake Moore1, Tina Etminan1, Brent Orr2, Joseph Chewning1, David Crossman1, G. Yancey Gillespie1
1The University of Alabama at Birmingham, USA, 2St. Jude Children's Research Hospital, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Use of IV N-acetylcysteine in combination with sodium thiosulfate for prevention of ototoxicity in pediatric patients
Edward Neuwelt*1,2, Nancy Doolittle1, Kristin Knight1, Susan Lindemulder1
1Oregon Health & Science University, USA, 2Portland Veterans Affairs Medical Center, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Using a zebrafish pediatric brain tumor model for pre-clinical drug screening
Katarzyna Modzelewska*1,2, Daniel Picard3,4, Elena Boer1,2, Rodney Miles2,6, Randy Jensen1,2, Theodore Pysher5,6, Joshua Schiffman1,5, Cicely Jette1,2, Annie Huang3,4, Rodney Stewart1,2
1Huntsman Cancer Institute, USA, 2University of Utah, USA, 3Arthur and Sonia Labatt Brain Tumour Research Centre, Canada, 4Hospital for Sick Children, Canada, 5Primary Children's Hospital, USA, 6ARUP, USA
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Very encouraging long-term survival and neurocognitive outcome of young children treated for medulloblastoma with sequential high dose chemotherapy
Lucie Lafay-Cousin6, Susan Chi2, Amy Smith3, Elizabeth Wells7, Jennifer Madden5, Ashley Margol4, Vijay Ramaswamy1, Emily Owen3, Douglas Strother1, Girish Dhall4, Nicholas Foreman5, Roger Packer7, Eric Bouffet*1
1The Hospital for Sick Children, Canada, 2Dana-Farber Cancer Institute, USA, 3Arnold Palmer Hospital for Children, USA, 4Children's Hospital of Los Angeles, USA, 5Children's Hospital of Colorado, USA, 6Alberta Children's Hospital, Canada, 7Children's National Medical Center, USA
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
When to biopsy a pineal region mass in children
Craig Erker*, Subramanian Subramanian, Teresa Kelly, Sachin Jogal
Medical College of Wisconsin, USA
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
WIP1 augments sonic hedgehog (SHH) signaling and is a target in SHH medulloblastomas
Juhyun Lee1, Meghan Buss1, Jing Wen1, Marc Remke3,4, Michael Taylor3,4, Robert Castellino*2,1
1Emory University, USA, 2Aflac Cancer and Blood Disorders Center, USA, 3University of Toronto, Canada, 4The Hospital for Sick Children, Canada
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am