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Featured Poster Discussion: 5:30pm - 6:10pm
Thursday, May 7

MODERATORS: Eric Raabe, Robert Wechsler-Reya
MB-15 Activated Wnt signaling targets Sox2+ treatment-refractory Shh-dependent medulloblastoma stem cells
Branavan Manoranjan*1, Chitra Venugopal1, Sujeivan Mahendram1, Steven Moreira1, Robin Hallett1, Thusyanth Vijayakumar1, David Bakhshinyan1, Nicole McFarlane1, John Hassell2, Bradley Doble1, Sheila Singh1,3
1McMaster Stem Cell & Cancer Research Institute, McMaster University, Canada, 2Department of Pathology & Molecular Medicine, Faculty of Health Sciences, McMaster University, Canada, 3Department of Surgery, Faculty of Health Sciences, McMaster University, Canada
MB-17 Novel candidate oncogenic drivers in pineoblastoma
Matija Snuderl*1, Kasthuri Kannan1, Olga Aminova1, Igor Dolgalev1, Adriana Heguy1, Arline Faustin1, David Zagzag1, Sharon Gardner1, Jeffrey Allen1, Jeffrey Wisoff1, David Capper2, Volker Hovestadt2, Sama Ahsan3, Charles Eberhart3, Stefan Pfister2, David Jones2, Matthias Karajannis3
1NYU Langone Medical Center, USA, 2German Cancer Research Center, Germany, 3Johns Hopkins University, USA
MB-33 The critical role of Olig2-expressing progenitors in the initiation of G-protein mediated Sonic Hedgehog-driven medulloblastoma
Xuelian Lu, Richard Lu*
Cincinnati Children's Hospital Medical Center, USA
PM-12 Using a zebrafish pediatric brain tumor model for pre-clinical drug screening
Katarzyna Modzelewska*1,2, Daniel Picard3,4, Elena Boer1,2, Rodney Miles2,6, Randy Jensen1,2, Theodore Pysher5,6, Joshua Schiffman1,5, Cicely Jette1,2, Annie Huang3,4, Rodney Stewart1,2
1Huntsman Cancer Institute, USA, 2University of Utah, USA, 3Arthur and Sonia Labatt Brain Tumour Research Centre, Canada, 4Hospital for Sick Children, Canada, 5Primary Children's Hospital, USA, 6ARUP, USA
OT-09 Characterization of infiltrating myeloid cells associated with xenografted gliomas in the rodent brain
Josh Morganti, Sharon Liu, Susanna Rosi, Nalin Gupta*
University of California San Francisco, USA
MB-03 Functional characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes
Lisa Liang*1, Christopher Aiken1, Robyn McClelland1, Ludivine Morrison1, Marc Remke2, Vijay Ramaswamy2, Marc Del Bigio1, Michael Taylor2, Tamra Werbowetski-Ogilvie1
1University of Manitoba, Canada, 2The Hospital for Sick Children, Canada
HG-09 Infantile glioblastoma with sarcomatous histology driven by ETV6:NTRK3 fusions are sensitive to Trk inhibition by PHA-848125
Diana Carvalho*1, Katy Taylor1, Anna Burford1, Ilona Nowak1, Alan Mackay1, Mara Vinci1, Lynn Bjerke1, Valeria Molinari1, Meera Nandhabalan1, Wendy Ingram2, Alexa Jury1, Rachael Natrajan1, David Jones3, Stefan Pfister3, Ludmila Shats4, Andrew Moore2, Thomas Jacques5, Sergey Popov1, Chris Jones1
1Institute of Cancer Research, UK, 2Queensland Childrens Medical Research Institute, Australia, 3DKFZ, Germany, 4Hospital #31, Russia, 5Great Ormond Street Hospital, UK
LG-03 Radiation therapy is associated with increased late mortality in long-term adult survivors of childhood low grade glioma: A population based study
Rahul Krishnatry*1,2, Nataliya Zhukova1, Ana Guerreiro Stucklin1, Jason Pole8, Matthew Mistry1, Vijay Ramaswamy1, Ute Bartels1, Annie Huang1, Normand Laperriere1,2, Peter Dirks1, Shayna Zelcer3, Mariana Silva4, Donna L Johnston5, Katrin Scheinemann6, Cynthia Hawkins1, Pratiti Bandopadhayay7, Mark W Kieran7, Peter E Manley7, Eric Bouffet1, Uri Tabori1
1The Hospital for Sick children, Canada, 2Princess Margret Hospital, Canada, 3London Health Sciences Centre, Canada, 4Kingston General Hospital, Canada, 5CHEO Research Institute, Canada, 6McMaster Children's Hospital, Canada, 7Dana-Farber Cancer Institute, USA, 8Pediatric Oncology Group of Ontario, Canada