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Poster Reception
Thursday, May 7, 5:30pm - 7:30pm

AT-02 The Hippo pathway activity in AT/RT
Mario Suzuki*, Akihide Kondo, Ikuko Ogino, Hajime Arai
Department of Neurosurgery, Juntendo University School of Medicine, Japan
BI-01 4EBP1 participates in cisplatin resistance of human glioma cells through PI3K/AKT/mTOR pathway
Li Bie*, Cong Hua, Lei Liu, Hongyan Yuan
The First Hospital of Jilin University, China
BI-02 Disruption of perivascular astrocytic foot processes characterizes MRI enhancement in pediatric brain tumors
Christopher Hong, Martin Piazza*, Winson Ho, Zhengping Zhuang
National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch, USA
BI-04 PID1 is a chemotherapy sensitizer and candidate tumor suppressor in medulloblastoma
Jingying Xu1, Xiuhai Ren1, Gregory M Shackleford1, Rex Moats1,2, Anat Erdreich-Epstein*1,2
1Children's Hospital Los Angeles, USA, 2University of Southern California, USA
BT-01 Tenascin-C: A novel therapeutic target in pediatric brainstem glioma
Amanda Saratsis*1,2, Madhuri Kambhampati3, Jordan Hall3, Mojca Stampar3, Guifa Xi2, Eric Raabe4, Roger Packer3, Javad Nazarian3
1Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 2Northwestern University Feinberg School of Medicine, USA, 3Children's National Medical Center, USA, 4Johns Hopkins University School of Medicine, USA
BT-04 A standardized autopsy procurement allows for the comprehensive study of DIPG biology
Madhuri Kambhampati1, Jenifer Perez1, Sridevi Yadavilli1, Amanda Saratsis1,2, Ashley Hill1, Cheng-Ying Ho1, Eshini Panditharatna1,3, Melissa Markel4, Roger Packer1, Javad Nazarian*1,3
1Children's National Medical Center, USA, 2Ann & Robert H. Lurie Children’s Hospital of Chicago, USA, 3George Washington University, USA, 4Riley Hospital for Children, USA
BT-07 Measuring tumor metabolism in diffuse intrinsic pontine gliomas (DIPG) using hyperpolarized carbon-13 MR spectroscopic imaging
Ilwoo Park*1, Rintaro Hashizume2, Xiaodong Yang3, Peder Larson1, C. David James2, Daniel Vigneron1, Sabine Mueller3,4, Sarah Nelson1,5
1Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco,, USA, 2Neurological Surgery and Biochemistry and Molecular Genetics, USA, 3Brain Tumor Research Center, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, USA, 4Department of Neurology, University of California, San Francisco, USA, 5Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco,, USA
BT-08 Autopsy derived orthotopic xenograft (ADOX) mouse models for terminal pediatric brain tumors
Qi Li1, Patricia Baster1, Mari Kogiso1, Yuchen Du1, Holly Lindsay1, Zhigang Liu1, Xiumei Zhao1, Jack Su1, Adekunle Adesina1, Andrew Walter5, Jeffrey Murray2, Rene McNall-Knapp3, Javad Nazarian4, Will Parsons1, Murali Chintagumpala1, Susan Blaney1, Xiao-Nan Li*1
1Texas Children's Cancer Center, Baylor College of Medicine, USA, 2Cook Children's Hospital, USA, 3Jimmy Everest Center for Cancer and Blood Disorders in Children, USA, 4Children's National Mediacal Center, USA, 5duPont Hospital for Children, USA
BT-09 Trilexium inhibits the expression of t-NOX and is a novel, potentially potent therapy for Diffuse Intrinsic Pontine Gliomas
Anne Kankean*1, Anahid Ehteda1, Arjanna Chitranjan1, Maria Tsoli1, Eleanor Ager2, David Ziegler1
1University of New South Wales, Australia, 2Novogen, Australia
EP-01 Heterogeneity of RelA protein expression in paediatric ependymoma
Tim Ritzmann*, Hazel Rogers, Jennifer Ward, Richard Grundy
Children's Brain Tumour Research Centre, The University of Nottingham, UK
EP-02 Molecular classification of ependymomas in  a Japanese cohort
Kohei Fukuoka*1,8, Shintaro Fukushima1,8, Satoshi Yamashita2, Tomoko Shofuda3,8, Taishi Nakamura1,8, Kai Yamasaki1,8, Hirokazu Takami1,8, Yuko Matsushita1,8, Toshikazu Ushijima2, Yoshitaka Narita4,8, Yonehiro Kanemura3,8, Mami Yamasaki5,8, Soichiro Shibui4,8, Hajime Arai6,8, Ryo Nishikawa7,8, Koichi Ichimura1,8
1Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Japan, 2Division of Epigenetics, National Cancer Center Research Institute, Japan, 3Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Japan, 4Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Japan, 5Department of Pediatric Neurosurgery, Takatsuki General Hospital, Japan, 6Department of Neurosurgery, Juntendo University, Japan, 7Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Japan, 8Japan Pediatric Molecular Neuro-Oncology Group (JPMNG), Japan
GC-03 Intracranial nongerminomatous germ cell tumors: treatment strategies and outcomes
Brandon Imber*1, Steve Braunstein1, Anuradha Banerjee3, Tarik Tihan4, Andrew Bollen4, Daphne Haas-Kogan1,5, Sabine Mueller2,3
1Department of Radiation Oncology, University of California, San Francisco, USA, 2Department of Neurology, Division of Child Neurology, University of California, San Francisco, USA, 3Department of Pediatrics, University of California, San Francisco, USA, 4Department of Pathology, University of California, San Francisco, USA, 5Department of Neurosurgery, University of California, San Francisco, USA
GE-01 IDH1-mutated pituitary adenoma challenges traditional characterization of Maffucci syndrome
Christopher Hong*1, Shuyu Hao2, Jie Feng2, Chunzhang Yang1, Prashant Chittiboina1, Junting Zhang3, Zhengping Zhuang1
1National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch, USA, 2Beijing Tiantan Hospital, Capital Medical University, China, 3Beijing Neurosurgical Institute, Capital Medical University, China
GE-02 Paradoxical genetic and epidemiologic relationships between cancer and autism
Rohini Singh*, Benjamin Darbro, Alexander Bassuk
University of Iowa, USA
GE-03 High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglial-like leptomeningeal tumors
Matthew J Schniederjan*1,2, Fausto J Rodriguez3, Theo Nicolaides4, Tarik Tihan4, Peter C Burger3, Arie Perry4
1Children's Healthcare of Atlanta, USA, 2Emory University School of Medicine, USA, 3Johns Hopkins University, USA, 4University of California San Francisco School of Medicine, USA
GE-04 Comprehensive genomic profiling (CGP) of pediatric gliomas reveals a high frequency of clinically relevant genomic alterations (CRGA) associated with benefit from targeted therapy
Zachary R Chalmers*1, Siraj M Ali1, Garrett M Frampton1, Juliann Chmielecki1, Norma A Palma1, Julia A Elvin1, Adrienne Johnson1, Roman Yelensky1, Jeffery S Ross1,4, Phillip J Stephens1, Vincent A Miller1, Angela J Waanders2, John Crawford3
1Foundation Medicine Inc, USA, 2Children's Hospital of Philadelphia, USA, 3Rady Children's Hospital San Diego, USA, 4Albany Medical Center, USA
GE-05 Study of epigenetic deregulation of a novel deubiquitylase in medulloblastoma
Rashieda Hatcher*1, Chandra Das1, Jason Fangusaro2, Veena Rajaram3, Rishi Lulla2, Stewart Goldman2, Soumen Khatua1, Gianluca Sbardella4, Vidya Gopalakrishnan1
1Children's Cancer Hospital and UT MD Anderson Cancer Center, USA, 2Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, USA, 3Children's Hospital and UT Southwestern Medical Center, USA, 4University of Salerno, Italy
GE-06 Identification of targetable mutations in rare pediatric brain tumors by clinical whole exome sequencing
Frank Y. Lin*, Abhishek Bavle, David Wheeler, Richard Gibbs, Sandi Lam, Jack Su, Murali Chintagumpala, Adekunle Adesina, Angshumoy Roy, Sharon E. Plon, D. Williams Parsons
Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, USA
GE-07 DNA methylation in medulloblastoma and molecular diagnostics of brain tumors
Volker Hovestadt*1, David Capper2,5, Martin Sill3, Simone Picelli1, Wei Wang1, Paul A. Northcott4, Marcel Kool4, Marc Zapatka1, Bernhard Radlwimmer1, Andreas von Deimling2,5, Stefan M. Pfister4,6, Peter Lichter1, David T. W. Jones4
1Division of Molecular Genetics, German Cancer Research Center (DKFZ), Germany, 2CCU Neuropathology, German Cancer Research Center (DKFZ), Germany, 3Division of Biostatistics, German Cancer Research Center (DKFZ), Germany, 4Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 5Department of Neuropathology, Heidelberg University Hospital, Germany, 6Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Germany
GE-08 Impact of H3.3K27M mutation on cancer epigenome
Dong Fang, Zhiguo Zhang*
Mayo Clinic, USA
HG-01 MGMT promoter methylation status and miRNA-181 family expression as prognostic markers in glioblastoma patients
Li Bie*, Cong Hua, Gang Zhao, Yuanqian Li
The First Hospital of Jilin University, China
HG-03 A novel mouse model of young adult glioblastoma: In vivo expression of mutated IDH1 (R132H) gene using the Sleeping Beauty Transposase System
Felipe J. Nunez*, Flor M. Mendez, Carl Koschmann, Alexandra Calinescu, Marta Dzaman, Pedro R. Lowenstein, Maria G. Castro
University of Michigan, USA
HG-05 Daam2 promotes tumor proliferation and migration in glioblastoma
Wenyi Zhu*1, Hyun-Kyoung Lee1, Joseph Loturco3, Carrie Mohila2, Benjamin Deneen1
1Baylor College of Medicine, USA, 2Texas Children's Hospital, USA, 3University of Connecticut, USA
HG-06 Inhibition of epigenetic regulation as a therapy for pediatric high grade glioma
Stephen Dombrowski*1, Thamara Abou-Antoun2, Stephen Mack3, Xiao-Nan Li4, Peter Houghton5, Darell Bigner6, Jeremy Rich3, Violette Recinos1
1Department of Neurological Surgery, Pediatric Neurosurgical Oncology, Cleveland Clinic, USA, 2Department of Natural Sciences, Lebanese American University, Lebanon, 3Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, USA, 4Laboratory of Molecular Neuro-Oncology, Texas Children's Hospital, Baylor College of Medicine, USA, 5Nationwide Children's Hospital, USA, 6Division of Neurosurgery, Department of Surgery, Duke University Medical Center, USA
HG-07 Detection of K27M mutant pediatric glioblastomas by immunohistochemistry
Sriram Venneti*1, Mariarita Santi2, Michelle Madden Felicella3, Dmitry Yarilin4, Joanna Phillips5, Lisa Sullivan2, Daniel Martinez2, Arie Perry5, Peter Lewis6, Craig Thompson4, Alexander Judkins7
1University of Michigan, USA, 2Children’s Hospital of Philadelphia, USA, 3Henry Ford Health System, USA, 4Memorial Sloan Kettering, USA, 5University of California, San Francisco, USA, 6University of Wisconsin-Madison, USA, 7Children’s Hospital Los Angeles, USA
HG-10 Hypoxia pathway driven by HIF-1alpha are predominantly involved in pediatric high grade glioma and represent promising therapeutic targets
Christelle Lasthaus1, Marie Litzler1, Cyril Bour1, Dominique Guenot1, Natacha Entz-Werlé*1,2
1EA3430, University of Strasbourg, France, 2pediatric Oncology, France
HG-12 LIN28 and MYC expressing pediatric glioblastomas are sensitive to inhibitors of glutamine metabolism
Isabella Taylor*, Sama Ahsan, Melanie Weingart, Charles Eberhart, Eric Raabe
Johns Hopkins Hospital, USA
HG-15 Targeted next generation sequencing in malignant supratentorial pediatric brain tumors reveals actionable mutations
Bonnie Cole1, Colin Pritchard2, Maia Anderson1, Sarah Leary*1,3
1Seattle Children's, USA, 2University of Washington, USA, 3Fred Hutchinson Cancer Research Center, USA
HG-16 The anti-apoptotic protein ARC is over-expressed in malignant glioma and correlates with patient outcome
Anne Kankean*, Maria Tsoli, Joanna Tsang, Arjanna Chitranjan, Sanaz Maleki, Kerrie McDonald, David Ziegler
University of New South Wales, Australia
HG-17 The histone deacetylase inhibitor PCI-24781 shows antiproliferative, pro-apoptotic and radiosensitizing effects on pediatric glioblastoma cell-lines
Pamela Viani Andrade, Augusto Faria Andrade, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera*
Faculdade de Medicina de Ribeirão Preto, USP., Brazil
HG-18 A role of spindle cells in glioblastoma growth
Shoko Yamada1, Lue Sun2, Shokei Yamada*3
1Teikyo University Mizonokuchi Hospital, Japan, 2Tsukuba University, Japan, 3Loma Linda University School of Medicine, USA
IM-04 Delta-24-RDG as an alternative therapeutic tool for pHGG/DIPG
Naiara Martinez-Velez*1, Enric Xipell1, Hong Jiang2, Cande Gómez-Manzano2, Juan Fueyo2, Marie-Pierre Junier3, Hervé Chneiweiss3, Elias El Habr3, Michelle Monje4, Oren Becher5, Marta M Alonso1
1Clinica Universidad de Navarra, Spain, 2MD Anderson Cancer Center, USA, 3Inserm, France, 4Stanford University, USA, 5Duke University School Medicine, USA
IM-05 Multispecific CAR T cells for the treatment of high grade glioma
Kevin Bielamowicz*, Kristen Fousek, Tiara Byrd, Kevin Chow, Zhongzhen Yi, Simone Krebs, Gianpietro Dotti, Stephen Gottschalk, Meena Hegde, Nabil Ahmed
Baylor College of Medicine, USA
IM-06 A bioinformatics evaluation of tumor-associated macrophages across 2 brain tumor types
Wan-Yee Teo*1,2, Sekar Karthik1, Seshachalam Veerabrahma Pratap1, Xiaonan Li3,4, Jianhe Shen3,4, M. Tarek Elghetany3,4, Kam-Man Hui1, Ching C Lau3,4
1Humphrey Oei Institute of Cancer Research, National Cancer Center Singapore, Singapore, 2KK Women’s & Children’s Hospital, Duke-NUS Singhealth Academic Partners in Medicine, Singapore, 3Texas Children’s Hospital, USA, 4Baylor College of Medicine, USA, 5Dan L. Duncan Cancer Center, USA
IM-07 NK cell immunotherapy for pediatric brain tumors: overcoming resistance to expand therapeutic success
William Brugmann*1, Alvaro Laureano4, Keith Michel1, Rong-Hua Tao1, Bridget Kennis1, Srinivas Somanchi1, Cecele Denman1, King Ching Ho3, Lucia Silla4, Harjeet Singh1, Helen Huls1, David Sandberg2, Dean Lee1, Jim Bankson1, Annie Huang3, Laurence Cooper1, Vidya Gopalakrishnan1
1University of Texas M.D. Anderson Cancer Center, USA, 2University of Texas Health Science Center, USA, 3Hospital for Sick Children, Canada, 4Centro de Tecnologia e Terapia Celular do Hospital de Clínicas de Porto Alegre, Brazil
IM-08 Inflammation driver, NF-kB, is associated with poor outcome Group A ependymoma and regulates a key immune suppressive signaling pathway involved in the tumor microenvironment
Andrea Griesinger*1,2, Andrew Donson1,2, Jean Mulcahy Levy1,2, Vladimir Amani1,2, Diane Birks1,2, Rajeev Vibhakar1,2, Michael Handler1,2, Nicholas Foreman1,2
1University of Colorado Denver, Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA
IM-10 Effects of T-cell TGF-β signaling abrogation on survival in pediatric glioma
Joshua Breunig*, Moise Danielpour, Rachelle Levy, Marina Dutra-Clarke
Cedars-Sinai, USA
IM-11 GBM-associated exosome-pulsed autologous DC vaccine (DC-Vex®) induces D-2 apoptotic-stage and bystander killing-effect in GBM of the mesenchymal type
John Giannios
Int Soc of Molecular and Genomic Medicine and Int Assoc of Perioperative Medicine and Nanosurgery, Greece
IM-12 RNA nanoparticle vaccines re-program host immunity in favor of enhanced effector responses against intracranial malignancies
Elias Sayour1,2, Gabriel De Leon1,2, Christina Pham1,2, Catherine Flores1, Luis Sanchez-Perez2, Duane Mitchell*1
1University of Florida, USA, 2Duke University, USA
IM-13 Molecular engineering of amplified tumor RNA-pulsed dendritic cells in adoptive cellular therapy targeting medulloblastoma and glioblastoma
Oleg Yegorov*, Jeffery Drake, Duane Mitchell
University of Florida, USA
IM-14 Immunologic targeting of medulloblastoma subtypes using developmentally regulated antigens
Christina Pham*1, Catherine Flores1, Yanxin Pei2, Robert Wechsler-Reya2, Duane Mitchell1
1University of Florida, USA, 2Sanford-Burnham Medical Research Institute, USA, 3Duke University, USA
IM-15 Anti-tumor efficacy of adoptive cellular therapy is significantly increased by hematopoietic stem cells
Catherine Flores*, Christina Pham, Tyler Wildes, Rebecca Abraham, Jeffrey Drake, Duane Mitchell
University of Florida, USA
LG-02 Challenges in the management of hypothalamic juvenile pilocytic astrocytoma
William Gump*1,2, Ian Mutchnick1,2, Jennifer Elster1,3, Kanyalakshmi Ayyanar1,3
1Kosair Children's Hospital, USA, 2Norton Neuroscience Institute, USA, 3University of Louisville School of Medicine, USA
LG-04 Notch signaling activation in pediatric low-grade astrocytoma
William D. Brandt1, Karisa C. Schreck1, Eli E. Bar2, Isabella Taylor1, Luigi Marchionni1, Eric Raabe1, Charles G. Eberhart1, Fausto J. Rodriguez*1
1Johns Hopkins University, USA, 2Case Western Reserve University, USA
LG-05 Pediatric grade II glioma molecular screening in adolescents and young adults
Irene Ollivier1,2, Christelle Lasthaus1, Marie Litzler1, Dominique Guenot1, Natacha Entz-Werlé*1,3
1EA3430, University of Strasbourg, France, 2Neurosurgery, France, 3pediatric Oncology, France
MB-01 Notch1 promotes MYC medulloblastoma metastasis, initiation and maintenance
Suzana Kahn*1,2, Ryan Nitta1, Kevin Wang3, Sharareh Gholamin1,2, Tej Azad1, Michael Zhang1, Yoon-Jae Cho1, Michael Taylor3, Siddhartha Mitra1,2, Irving Weissman2, Samuel Cheshier1
1Neurosurgery Department, Stanford University, USA, 2Institute for Stem Cell Biology and Regenerative Medicine, USA, 3The Hospital for Sick Children, Canada
MB-04 Expression of CRMP1 inhibits cell proliferation of medulloblastoma and is regulated by HMGA1
Ho-Keung Ng*1,2, Ka Wai Kay Li1,2, Yan Qi1, Xia Tian1, Yu Yao3, Liangfu Zhou3, Kin-Mang Lau1
1Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, 2Shenzhen Research Institute, The Chinese University of Hong Kong, China, 3Department of Neurosurgery, Huashan Hospital, Fudan University, Hong Kong
MB-05 Pharmacological inhibition of MRK/ZAK kinase for the treatment of medulloblastoma
Rosamaria Ruggieri*1, Daniel Markowitz1, Caitlin Powell1, Nhan Tran2, Magimairajan Vanan3, Mingzu He1, Yousef Al Abed1, Marc Symons1
1The Feinstein Institute, USA, 2Translational Genomics Research Institute, USA, 3University of Manitoba, Canada
MB-06 Prognostic impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in medulloblastoma
Akihide Kondo*, Tomoko Kurimoto, Sachi Sakaguchi, Hajime Arai
Juntendo University, Japan
MB-07 Primary Ewing sarcoma of the scalp with apparent epidural extension: case illustration
William Gump*1,3, Robert Debski1, Matthew Thompson1, Kanyalakshmi Ayyanar1,2
1Kosair Children's Hospital, USA, 2University of Louisville School of Medicine, USA, 3Norton Neuroscience Institute, USA
MB-09 Aggressive medulloblastoma subverts the photoreceptor specific transcription factor NRL
Alexandra Garancher1, Morgane Morabito1, Nathalie Rocques1, Magalie Larcher1, Catherine Micquel2, Stéphanie Puget3, François Doz4, Olivier Delattre5, Olivier Ayrault1, Alain Eychène1, Franck Bourdeaut1, Celio Pouponnot*1
1Institut Curie/ CNRS UMR3347 / INSERM U1021, France, 2Universite Paris Descartes, France, 3Hopital Necker, France, 4Institut Curie / Service de Pédiatrie, France, 5Institut Curie / U830 INSERM, France
MB-10 GSK-3 promotes proliferation during postnatal cerebellar development and may be targeted in medulloblastoma therapy
Jennifer Ocasio*, Timothy Gershon
University of North Carolina, USA
MB-11 Impact of molecular sub-type and craniospinal irradiation (CSI) dose on relapse of medulloblastoma
Ange Wang*1, Sonia Partap1, Kristen Yeom1, Mesha Martinez2, Hannes Vogel1, Sarah Donaldson1, Paul Fisher1, Sebastien Perreault3, Yoon-Jae Cho1, Iris Gibbs1
1Stanford University School of Medicine/Lucille Packard Children's Hospital, USA, 2Temple University, USA, 3University of Montreal-CHU Sainte-Justine, Canada
MB-12 Induced cisplatin resistance in medulloblastomas
Michael Feldman*1,2, Winson Ho1, John Heiss1, Matthew Hall3, Zhenping Zhuang1
1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, USA, 2University of Rochester School of Medicine and Dentistry, USA, 3Laboratory of Cell Biology, National Cancer Institute, NIH, USA
MB-13 HDAC and PI3K antagonists cooperate to inhibit growth of MYC-driven medulloblastoma
Kun-Wei Liu*1, Yanxin Pei1,2, Robert Wechsler-Reya1
1Sanford-Burnham Medical Research Institute, USA, 2Children’s National Medical Center, USA
MB-16 Boost volume effects on incidental hippocampal dose in pediatric medulloblastoma
Palak Kundu*, Iris Gibbs
Stanford University School of Medicine, USA
MB-18 Post-translational regulation of Atoh1: from cerebellar development to medulloblastoma formation
Sara Maria Cigna**1, Antoine Forget*1, Laure Bihannic1, Marc Remke2, Sandrine Humbert1, Michael D. Taylor2, Anna Lasorella3, Olivier Ayrault1
1Institut Curie, France, 2Hospital for Sick Children, University of Toronto, Canada, 3Institute for Cancer Genetics, Columbia University Medical Center, USA
MB-20 Evaluating the oncogenic potential of TSC1/2 mutations and efficacy of MTOR inhibitors in high risk pediatric medulloblastoma
Jacob Henderson*, Jacob Wagner, Monika Davare
Doernbecher Children's Hospital OHSU, USA
MB-22 Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in myc-driven medulloblastoma
Eric Prince*, Monil Shah, Sujatha Venkataraman, Ilango Balakrishnan, Irina Alimova, Peter Harris, Diane Birks, Andrew Donson, Michael Taylor, Michael Handler, Nicholas Foreman, Rajeev Vibhakar
University of Colorado Anschutz Medical Campus, USA
MB-26 Targeting medulloblastoma with a new small-molecule drug that inhibits MYC mediated translation
Bronwen Foreman*, Irina Alimova, Peter Harris, Ilango Balakrishnan, Eric Prince, Nicholas Foreman, Rajeev Vibhakar, Sujatha Venkataraman
University of Colorado, Anschutz Medical Campus, USA
MB-28 Genome-wide copy number analysis, neuropathological classification and analysis of hedgehog activation: Histology reflects genetics and biology in medulloblastomas of young children
Elena Kapitza1, Dorota Denkhaus1, Anja zur Mühlen1, Stefan Rutkowski2, Torsten Pietsch*1
1Department of Neuropathology and Brain Tumor Reference Center, University of Bonn, Germany, 2Department of Pediatric Hematology and Oncology, University Clinics of Hamburg-Eppendorf, Germany
MB-29 Dissecting the role of epigenetic modulators in Shh-driven medulloblastoma
Tara Dobson*1, Rong-Hua Tao1, Shavali Shaik1, Pete Taylor1, Rashieda Hatcher1, Ellen Busschers1, Soumen Khatua1, Stewart Goldman2, Rishi Lulla2, Veena Rajaram3, Tobey MacDonald4, Jason Fangusaro2, Vidya Gopalakrishnan1
1University of Texas MD Anderson Cancer Center, USA, 2Northwestern University, USA, 3University of Texas Southwestern Medical Center, USA, 4Emory University, USA
MB-30 Oncolytic picornavirus SVV-001 prolongs animal survival in a patient tumor-derived orthotopic xenograft mouse model of Group 3 supratentorial primitive neuroectodermal tumor
Zhigang Liu2,1, Lin Qi1, Xiu Mei Zhao1, Yulun Huang1, Mari Kogiso1, Yuchen Du1, Holly Lindsay1, Patricia Baxter1, Jack Su1, Adekunle Adesina1, Murali Chintagumpala1, Xiao-Nan Li*1
1Texas Children's Hospital, Baylor College of Medicine, USA, 2Diana Helis Henry Medical Research Foundation, USA
MB-31 MicroRNA expression patterns in tissue and cerebrospinal fluid aid in molecular classification of pediatric medulloblastoma
Rishi Lulla*1, Joseph Laskowski1, Yingtao Bi2, Stewart Goldman1, Jason Fangusaro1, Vidya Gopalakrishnan3
1Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, USA, 2in Preventive Medicine-Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, USA, 3Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center,, USA
MB-32 Feasibility of vorinostat combined with isotretinoin and chemotherapy for young children with newly diagnosed embryonal brain tumors: A Pediatric Brain Tumor Consortium Study
Sarah Leary*1,4, Lindsay Kilburn2, J. Russell Geyer1,4, James M. Olson1,4, Tobey MacDonald8, David Ellison3, Mehmet Kocak3, Arzu Onar3, Ralph Ermoian6, Tina Young Poussaint7, James M. Boyett3, Larry Kun3, Maryam Fouladi3
1Seattle Children's, USA, 2Children's National Medical Center, USA, 3St. Jude Children's Research Hospital, USA, 4Fred Hutchinson Cancer Research Center, USA, 5Cincinnati Children's Hospital Medical Center, USA, 6University of Washington, USA, 7Dana Farber Cancer Institute, USA, 8Children's Healthcare of Atlanta, USA
MB-34 Molecular subgroups of medulloblastoma identification using non-invasive magnetic resonance spectroscopy
Ashley Margol*1,2, Stefan Bluml1,2, Richard Sposto1,2, Rebekah Kennedy1, Nathan Robison1,2, Marzieh Vali1, Long Hung1, Sakunthala Muthugounder1, Jonathan Finlay3, Anat Erdreich-Epstein1,2, Floyd Gilles1,2, Alexander Judkins1,2, Mark Krieger1,2, Girish Dhall1,2, Marvin Nelson1,2, Shahab Asgharzadeh1,2
1Children's Hospital Los Angeles, USA, 2University of Southern California, USA, 3Nationwide Children's Hospital, USA
MB-37 Metachronous supratentorial intracranial malignant tumors in two pediatric patients with infratentorial medulloblastoma on hormone therapy
Augustus Perez*, James Shiflett, Betty Herrington
University of MIssissippi Medical Center, USA
OT-01 Effectiveness of perfusion and diffusion imaging for grading pediatric brain tumors
Teresa Kelly*1,2, Melissa Prah2,3, Sachin Jogal1,2, Mohit Maheshwari1,2, Sean Lew1,2, Kathleen Schmainda2,3
1Children's Hospital of Wisconsin, USA, 2Medical College of Wisconsin, USA, 3Froedtert Hospital, USA
OT-02 Pediatric anaplastic meningioma: a case report successfully treated with combined chemotherapy for soft tissue sarcomas and radiotherapy.
Maurizio Lucchesi*1, Sabrina Becciani1, Anna Maria Buccoliero2, Alessia Stival1, Ludovica Facchini1, Silvia Farina1, Maurizio de Martino1, Iacopo Sardi1
1Neuro-oncology Unit, Department of Paediatric Medicine, Meyer Children's University Hospital, Italy, 2Pathology Unit, Meyer Children's University Hospital, Italy
OT-03 When to biopsy a pineal region mass in children
Craig Erker*, Subramanian Subramanian, Teresa Kelly, Sachin Jogal
Medical College of Wisconsin, USA
OT-04 Primary central nervous system non hodgkin lymphoma in a pediatric patient without immunodeficiency related. case report and literature review
Marco R. Aguilar-Ortiz*, Rocío Cardenas-Cardós, Liliana Velasco-Hidalgo, Pedro-Mario Pasquel-García-Vázquez, Roberto Rivera-Luna, Alfonso Marhx-Bracho
National Institute of Pediatrics (INP), Mexico
OT-06 Multicentric primary central nervous system diffuse large b cell lymphoma in an inmunocompetent adolescent, case report
Jose Leon*, Rocio Cardenas, Marta Zapata, Liliana Velasco
Instituto Nacional de Pediatria, Mexico
OT-07 Primary central nervous system melanocytic lesions in childhood: experience at National Institute of Pediatrics in Mexico
Yahiel Osorio-Alamillo*1, Marta Zapata-Tarres1, Ana Niembro1, Rodolfo Rodriguez-Jurado2, Pedro Pasquel -García2, Mauricio Rojas2, Rolando Jimenez-Guerra3, Leticia Munive4, Patricia Herrera4
1Instituto Nacional de Pediatria Oncology Department, Mexico, 2Instituto Nacional de Pediatria Pathology Department, Mexico, 3Instituto Nacional de Pediatria Neurosurgery Department, Mexico, 4Instituto Nacional de Pediatría Neurology Department, Mexico
OT-08 Distinct brain lineage and stromal gene expression patterns in WNT, SHH, Group 3 and Group 4 molecular subgroups of pediatric medulloblastoma
Achal Achrol2, Tiffany Liu4, Hannes Vogel3, Steven Chang2, Michael Edwards2, Griffith Harsh2, Debashis Sahoo*1
1Department of Pediatrics, University of California San Diego School of Medicine, USA, 2Department of Neurosurgery, Stanford University Medical Center, USA, 3Department of Pathology (Neuropathology), Stanford University Medical Center, USA, 4Department of Medicine (Stanford Center for Biomedical Informatics Research), Stanford University Medical Center, USA
PM-05 Tumor location remodels transcriptomic profiles in a pediatric medulloblastoma xenograft
Gregory Friedman*1, Li Nan1, Blake Moore1, Tina Etminan1, Brent Orr2, Joseph Chewning1, David Crossman1, G. Yancey Gillespie1
1The University of Alabama at Birmingham, USA, 2St. Jude Children's Research Hospital, USA
PM-07 Bcl-xL dependence of neural progenitors may be exploited to improve medulloblastoma therapy
Katherine Veleta*, Andrew Crowther, Timothy Gershon
University of North Carolina at Chapel Hill, USA
PM-08 A humanized co-transplant xenograft mouse model, to study toxicity of drugs targeted against pediatric brain tumors
Sharareh Gholamin*1,2, Suzana Assad Kahn1,2, Rogelio Esparza2, Gregor Hutter1,2, Abdullah Feroze2, Irving L. Weissman1, Siddhartha S. Mitra1, Samuel H. Cheshier1
1Stanford , Institute of Stem Cell Biology and Regenerative Medicine, USA, 2Stanford, department of Neurosurgery, USA
PM-09 Establishment and molecular characterization of patient-derived xenograft models of pediatric brain tumors
Sebastian Brabetz*1, Huriye Seker-Cin1, Susanne N. Gröbner1, Volker Hovestadt2, David T. W. Jones1, Paul A. Northcott1, Till Milde3,4, Jessica M. Rusert5, Kyle Pedro6, Karina Bloom6, Xiao-Nan Li7, Robert J. Wechsler-Reya5, James M. Olson6, Stefan M. Pfister1,4, Marcel Kool1
1Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 2Division of Molecular Genetics, German Cancer Research Center (DKFZ), Germany, 3CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Germany, 4Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany, 5Sanford-Burnham Medical Research Institute, USA, 6Fred Hutchinson Cancer Research Center and Seattle Children's Hospital, USA, 7Laboratory of Molecular Neuro-Oncology, Baylor College of Medicine, USA
PM-11 Development of a novel gene targeting and clone screening platform to engineer common pediatric glioma mutations into model cell lines
Nathan Fons*1,2, Ranjini Sundaram2, Ranjit Bindra1,2
1Experimental Pathology, Yale University, USA, 2Therapeutic Radiology, Yale University, USA
PM-14 A piggyBac toolkit for rapid testing of putative pediatric GBM driver genes with extensions for investigating cells of recurrence
Joshua Breunig*, Rachelle Levy, C. Danielle Antonuk, Jessica Molina-Aravena, Marina Dutra-Clarke, Aslam Akhtar, Gi Bum Kim, Hannah Park, Moise Danielpour
Cedars-Sinai, USA
SC-01 RalA in biology and therapy of MPNST in correlation to cancer stem cells
Kaoru Terai1, Emma Borrego-Diaz1, Darren Lovick2, Michael Salacz1, Adel Rezaei Moghadam1, Zohreh Sanaat1, Roya Dolatkhah1, Elham Patrad1, Mojtaba Amani1, Warner Peng1, Tuba Esfandyari1, Faris Farassati*1
1The University of Kansas Medical School, USA, 2The University of Missouri Kansas City-School of Medicine-St Luke's Hospital, USA
SC-03 Neural stem cell-mediated enzyme/prodrug therapy for medulloblastoma
Margarita Gutova1, Diana Oganesyan1, Silvia Tacheva Grigorova2, Yanxin Pei2, David Shahmanyan*1, Zhongqi Li1, Michael Barish1, Karen Aboody1, Robert Wechsler-Reya2
1City of Hope, USA, 2Sanford Burnham Research Institute, USA
SG-02 Role of mTOR signalling pathway in the pathogenesis of subependymal giant cell astrocytomas
Mehar Sharma*, Kalpana Kumari, Aanchal Kakkar, Chitra Sarkar, Vaishali Suri, Sarat Chandra
All India Institute of Medical Sciences, India
SG-03 A role for NADPH oxidase 4-generated reactive oxygen species in Sonic hedgehog-driven proliferation of cerebellar granule neuron precursors
Chad Potts*, Rachel Rotenberry, Anna Kenney
Emory University, USA
TR-01 Ezh2, a novel target in treatment of medulloblastoma
Brandon Ricke1, Kushal Shah1, Michael Salacz1, Paul Camarata1, Darren Lovick2, Warner Peng1, Roya Dolatkhah1, Zohreh Sanaat1, Kyle Kimura*1, Danse Bi1, Sarah Taylor1, Tuba Esfandyari1, Faris Farassati1
1The University of Kansas School of Medicine, USA, 2University of Missouri Kansas City School of Medicine-St Luke's Hospital, USA
TR-02 Inhibition of AKT signaling and tumor growth by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cell line in vitro and in nude mice xenografts
Cheppail Ramachandran*1,2, Gilda Portalatin1, Karl-Werner Quirin3, Enrique Escalon1, Ziad Khatib1, Steven Melnick1,2
1Miami Children's Hospital, USA, 2Dharma Biomedical LLC, USA, 33Flavex Naturextrakte GmbH, Germany
TR-03 Pharmacological modulation of blood-brain barrier: a novel therapeutic approach to refractory CNS tumors
Sabrina Becciani1, Martina Da Ros*1, Anna Lisa Iorio1, Laura Giunti1, Alessia Stival1, Maurizio Lucchesi1, Maura Massimino2, Maurizio de Martino1, Iacopo Sardi1
1Neuro-oncology Unit, Department of Paediatric Medicine, Anna Meyer Children's University Hospital, Italy, 2Department of Paediatrics, IRCCS Foundation, National Cancer Institute, Italy
TR-04 Nanoparticle siRNA delivery vehicles inhibit DNA repair and sensitize pediatric brain tumor cells to radiation therapy
Forrest Kievit*, Zachary Stephen, Kui Wang, Christopher Dayringer, John Silber, Richard Ellenbogen, Miqin Zhang
University of Washington, USA
TR-05 ER stress inducing drugs downregulates MGMT and MPG sensitizing pediatric glioma cell lines to TMZ
Enric Xipell*1, Naiara Martinez-Vélez1, Marisol Gonzalez-Huarriz1, Arlet Acanda de la Rocha1, Chris Jones2, Marta M. Alonso1
1University Hospital of Navarra, Spain, 2The Institute of Cancer Research, UK
TR-07 LB100, a novel protein phosphatase 2A inhibitor, enhances cisplatin and radiation mediated cytotoxicity and overcome cisplatin resistance in-vitro
Sze Chun Winson Ho*, Michael Feldman, Dragan Maric, John Heiss, Zhengping Zhuang
National Institute of Health, USA
TR-08 Targeted combinatorial approach for treatment of pediatric low grade gliomas in the context of BRAFV600E and KIAA1549:BRAF mutations
Aleksandra K. Olow*1, Sabine Mueller1, Xiaodong Yang1, Rintaro Hashizume2, Justin Meyerowitz1, William Weiss1, Adam C. Resnick3, Angela J. Waanders3, Mitchel S. Berger1, Nalin Gupta1, C. David James2, Daphne A. Haas-Kogan1
1University of California, USA, 2Northwestern University Feinberg School of Medicine, USA, 3The Children's Hospital of Philadelphia, USA
TR-09 The effect of regadenoson-induced transient disruption of the blood brain barrier on temozolomide delivery to rat brain parenchyma
Sadhana Jackson*, Nicole Anders, Antonella Mangraviti, Henry Brem, Betty Tyler, Michelle Rudek, Stuart Grossman
Johns Hopkins, USA
TR-10 Autophagy inhibition reverses resistance to targeted BRAF therapy in pediatric CNS tumors
Shadi Zahedi1, Andrea Griesinger1, Michael Handler2, Nicholas Foreman1, Andrew Thorburn1, Jean M. Mulcahy Levy*1
1University of Colorado Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA
TR-11 A molecular biology and phase II study of Imetelstat (GRN163L) in children with recurrent or refractory central nervous system (CNS) malignancies: a Pediatric Brain Tumor Consortium Study 
Ralph Salloum*1, Trent Hummel1, Shiva-Senthil Kumar1, Kathleen Dorris8, Shaoyu Li2, Tong Lin2, Arzu Onar-Thomas2, Lili Miles1, Tina Toung-Poussaint3, Charles Stevenson1, Stewart Goldman4, Girish Dhall5, Roger Packer6, Paul Fisher7, Maryam Fouladi1, James Boyett2, Rachid Drissi1
1Cincinnati Children's Hospital Medical Center, USA, 2St. Jude Children's Research Hospital, USA, 3Boston Children's Hospital of Chicago, USA, 4Ann and Robert H. Lurie Children's Hospital, USA, 5Children's Hospital of Los Angeles, USA, 6Children's National Medical Center, USA, 7Lucille Packard Children's Hospital Stanford, USA, 8Children's Hospital of Colorado, USA
TR-12 OKN-007: a novel compound for treating pediatric glioblastoma
Samantha Mallory*1,2, Rene McNall-Knapp1, Patricia Coutinho DeSouza2,3, Nataliya Smith2, Debra Saunders2, Kar-Ming Fung1, Rheal Towner1
1University of Oklahoma Health Science Center, USA, 2Oklahoma Medical Research Foundation, USA, 3Oklahoma State University, USA
TR-13 Effects of everolimus on meningioma growth in patients with neurofibromatosis Type 2
Diana Osorio*, Alexander Filatov, Mari Hagiwara, Carole Mitchell, Jeffrey Wisoff, John Golfinos, J. Thomas Roland, Jeffrey Allen, Matthias Karajannis
NYU Langone Medical Center, USA
TR-15 Use of IV N-acetylcysteine in combination with sodium thiosulfate for prevention of ototoxicity in pediatric patients
Edward Neuwelt*1,2, Nancy Doolittle1, Kristin Knight1, Susan Lindemulder1
1Oregon Health & Science University, USA, 2Portland Veterans Affairs Medical Center, USA
TR-16 Personalized targeted therapy in refractory or relapsed cancer in childhood (Triceps Study)
Sophie DUMOUCEL*, Michel DUVAL, Monia MARZOUKI, Henrique BITTENCOURT, Yvan SAMSON, Sonia CELLOT, Georges-Etienne RIVARD, Pierre TEIRA, Anne-Sophie CARRET, Jasmine HEALY, Dorothee DAL SOGLIO, Natacha PATEY, Nelson PICHE, Thomas SONTAG, Sylvie LANGLOIS, Mathieu LAJOIE, Daniel SINNETT
CHU Ste Justine, Canada
TR-17 Immunotargeted-molecular-robotic-nanosurgery(ITMRN) eradicates GBM stem-cells with radiofrequency dielectric heating(RFDH) mediated via silver-immunonanobots linked with anti-CD133 MAbs
John Giannios
Int Soc of Molecular and Genomic Medicine and Int Assoc of Perioperative Medicine and Nanosurgery, Greece