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Session 6 - Germ Cell Tumors/Choroid Plexus Tumors
Thursday, May 7, 3:40pm - 4:40pm

MODERATORS: Girish Dhall, Torsten Pietsch

 


PM-10 Genetically engineered mouse models of choroid plexus tumors
Jun Wang*1, Diana Merino3, Brian Murphy2, Girish Dhall4, Erin Kiehna4, Alexander Judkins4, David Ellison2, Charles Eberhart5, Scott Vandenberg6, David Malkin3, Richard Gilbertson2, Martine Roussel2, Robert Wechsler-Reya1
1Sanford-Burnham Medical Research Institute, USA, 2St. Jude Children's Research Hospital, USA, 3The Hospital for Sick Children, Canada, 4Children's Hospital of Los Angeles, USA, 5Johns Hopkins University School of Medicine, USA, 6University of California, San Diego, USA
PM-15 Notch and Shh signaling pathways converge on the primary cilium to promote choroid plexus tumor initiation from epithelial progenitors
Haotian Zhao*1,2, Li Li1, Katie Picotte1, Jun Wang3, Robert Wechsler-Reya3, Jasmin Ohli4, Ulrich Schüller4
1Sanford Research, USA, 2Sanford School of Medicine, University of South Dakota, USA, 3Sanford-Burnham Medical Research Institute, USA, 4Ludwig-Maximilans University, Germany
GC-02 CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways
Torsten Pietsch*1, Barbara Steiger1, Dorota Denkhaus1, Christian Vokuhl2, Ivo Leuschner2
1Department of Neuropathology & Brain Tumor Reference Center, University of Bonn, Germany, 2Department of Pediatric Pathology & Kiel Pediatric Tumor Registry, University of Kiel, Germany
GC-01 Elucidation of pathogenesis in intracranial germ cell tumors based on a genome-wide methylation study
Shintaro Fukushima1, Satoshi Yamashita2, Hirokazu Takami1, Kohei Fukuoka1, Yoshitaka Narita3, Toshikazu Ushijima2, Masao Matsutani4, Ryo Nishikawa4, Koichi Ichimura*1, Intracranial Germ Cell Tumors Genome Analysis Consortium1
1Division of Brain Tumor Translational Research, National Cancer Center Research Institue, Japan, 2Division of Epigenomics, National Cancer Center Research Institue, Japan, 3Department of Neurosurgery and Neurooncology, National Cancer Center Hospital, Japan, 4Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Japan
GC-04 Preliminary results of a feasibility pilot study of “Gempox” (gemcitabine, oxaliplatin, and paclitaxel) in pediatric and adult patients with refractory or recurrent central nervous system (CNS) germ cell tumors (GCT): the International CNS GCT Consortium Trial, CNS GCT- 4
Jonathan Finlay*1, Kelly Haley2, Girish Dhall2, Diana Osorio1, Sharon Gardner3, Jeffrey Allen3, Jeffrey Leonard1
1Nationwide Children's Hospital and The Ohio State University, USA, 2Children's Hospital Los Angeles, USA, 3The Stephen D. Hassenfeld Children's Cancer Center, New York University, USA
OT-10 Implementation of next generation copy number and mutational analysis in routine neuropathology: molecular inversion profiling is a helpful tool in differential diagnostics and prognostification of pediatric brain tumors
Torsten Pietsch*1, Marco Gessi1, Anja zur Mühlen1, Evelyn Dörner1, Andy Last2, Padma Sundar2
1Department of Neuropathology, Brain Tumor Reference Center, University of Bonn, Germany, 2Affymetrix, USA