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Session 5 - Low Grade Glioma
Thursday, May 7, 2:15pm - 3:15pm

MODERATORS: Nicholas Foreman, Cynthia Hawkins

 


LG-07 Mosaic genetic progression models of low grade pediatric brain tumors reveal unique features of tumor evolution
C. Danielle Antonuk, Rachelle Levy, Jessica Molina, Moise Danielpour, Aslam Akhtar, Joshua Breunig*
Cedars-Sinai, USA
LG-01 BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma
Matthew Mistry*1, Nataliya Zhukova1, Daniele Merico1, Patricia Rakopoulos1, Rahul Krishnatry1, Mary Shago1, Jim Stavropoulos1, Jason Pole2, Peter Ray1, Marc Remke1, Pawel Buczkowicz1, Vijay Ramaswamy1, Adam Shlien1, James Rutka1, Peter Dirks1, Michael Taylor1, David Malkin1, Eric Bouffet1, Cynthia Hawkins1, Uri Tabori1
1The Hospital for Sick Children, Canada, 2Pediatric Oncology Group of Ontario, Canada
LG-06 Effects of TORC1/2 inhibitor MLN0128 alone and in combination with MEK inhibition in BRAF mutated glioma cells
Sabine Mueller*1, Rogier Dik1, Xiaodong Yang1, Ola Aleksandra1, Clay Gustafson1, Steve DuBois1, William Weiss1, Angela Waanders2, Adam Resnick2, Daphne Haas-Kogan1
1University of California San Francisco, USA, 2University of Pennsylvania Perelman School of Medicine, The Children’s Hospital of Philadelphia, USA
SG-01 Feedback activation of EGFR via PTPN9 leads to glioma escape from BRAFV600E targeted therapy
Tsun-Wen Yao*1, Jie Zhang1, Michael Prados1, William Weiss1,2, David James3,4, Theodore Nicolaides1,2
1Departments of Pediatrics, UCSF, USA, 2Departments of Neurological Surgery, UCSF, USA, 3Departments of Neurological Surgery, Northwestern University, USA, 4Developmental Therapeutics Institute, Northwestern University, USA
TR-06 Combinatorial pathway targeting approaches for BRAF-fusions associated with pediatric low-grade gliomas
Angela Waanders1, Amanda Silva1, Shih-Shan Chen2, Harry Han2, Yuankun Zhu2, Katie Boucher2, Payal Jain*2, Tamara Fierst2, Namrata Choudhari2, Sabine Mueller3, Daphne Haas-Kogan4, Phillip Storm2, Adam Resnick2
1Division of Oncology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, The Children's Hospital of Philadelphia, USA, 2Department of Neurosurgery, University of Pennyslvania Perelman School of Medicine, The Children's Hospital of Philadelphia, USA, 3Department of Pediatrics, University of California, San Francisco, USA, 4Department of Radiation Oncology, University of California, San Francisco, USA