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Session 3 - Brainstem Gliomas/High Grade Gliomas
Thursday, May 7, 10:35am - 12:05pm

 

MODERATORS: Oren Becher, Jonathan Finlay

 


BT-06 PLK1 as a potential therapeutic target for DIPG
Vladimir Amani*1,2, Sujatha Venkataraman1,2, Eric Prince1,2, Diane Birks1,2, Ilango Balakrishnan1,2, Andrew Donson1,2, Andrea Griesinger1,2, Peter Harris1,2, Nicholas Foreman1,2, Rajeev Vibhakar1,2
1University of Colorado Anschutz Medical Campus, USA, 2The Children’s Hospital Colorado, USA
HG-14 Clinical, radiographic, and histologic characteristics of long-term survivors of diffuse intrinsic pontine glioma: a report from The International DIPG Registry
Lindsey M. Hoffman*1, Ute Bartels2, Lili Miles1, Cynthia Hawkins2, Stewart Goldman3, Sarah Leary4, Tim Hassal5, Jane Minturn6, Roger Packer7, Nicholas Foreman8, Kathy Warren9, Alberto Broniscer10, Emmett Broxon11, Chie-Schin Shih12, James Leach1, Blaise Jones1, Josh Baugh1, Brooklyn Hacker1, Brianna Lerme1, Chris Jones14, Sharon Savage9, Jenavieve Kirkendall1, Renee Doughman1, Matt Wollman1, Linwood Millett1, Rachel O'Keefe1, Eric Bouffet2, Dannis G. van Vuurden13, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2Hospital for Sick Children, Canada, 3Lurie Children's Hospital, USA, 4Seattle Children's Hospital, USA, 5Lady Cilento Children's Hospital, Australia, 6Children's Hospital of Philadelphia, USA, 7Children's National Medical Center, USA, 8Children's Hospital Colorado, USA, 9National Institute of Health, USA, 10St. Jude Children's Hospital Medical Center, USA, 11Dayton Children's Hospital, USA, 12Riley Children's Hospital, USA, 13VU University Medical Center, The Netherlands, 14Institute of Cancer Research, UK
IM-03 Serial metabolism of diffuse intrinsic pontine glioma treated with peptide based vaccine therapy
Ashok Panigrahy*1,2, Brenda Kurland1, Rafael Ceschin1, Shira Abberbock1, Hideho Okada3, Regina Jakacki1, Ian Pollack1, Stefan Bluml2
1Childrens Hospital of Pittsburgh, USA, 2Childrens Hospital of Los Angeles, USA, 3UCSF, USA
BT-03 Targeted inhbition of histone demethylase activity for the treatment of pediatric brainstem gliomas
Noemi Ander2, Robin Lerner2, Xi Huang2, Maxwell Tom2, Vy Ngo2, David Solomon1,3, Sabine Mueller2, Pamela Paris2, Zhiguo Zhang4, Nalin Gupta2, Todd Waldman3, Stewart Goldman1, David James1, Rintaro Hashizume*1
1Northwestern University, USA, 2University of California San Francisco, USA, 3Georgetown University School of Medicine, USA, 4Mayo Clinic, USA
BT-02 Functionally-defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso1,15, Yujie Tang*2,15, Nathalene Truffaux3,15, Noah E. Berlow4,16, Lining Liu2,16, Marie-Anne Debily3,5, Michael J. Quist1, Lara Davis6, Elaine C. Huang6, Pamelyn J. Woo2, Anitha Ponnuswami2, Spenser Chen2, Tessa Johung2, Wenchao Sun2, Mari Kogiso7, Yuchen Du7, Qi Lin7, Yulun Huang7,8, Marianne Hutt-Cabezas9, Katherine E. Warren10, Ludivine Le Dret3, Paul S. Meltzer10, Hua Mao7, Martha Quezado10, Dannis G. van Vuurden11, Jinu Abraham6, Maryam Fouladi12, Matthew N. Svalina6, Nicholas Wang1, Cynthia Hawkins13, Eric Raabe9, Esther Hulleman11, Paul T. Spellman1, Xiao-Nan Li7, Charles Keller6, Ranadip Pal4, Jacques Grill3,14, Michelle Monje2
1Center for Spatial Systems Biomedicine Department of Molecular and Medical Genetics, Oregon Health & Science University, USA, 2Depts. of Neurology, Neurosurgery and Pediatrics, Stanford University, USA, 3Unité Mixte de Recherche du Centre National de la Recherche Scientifique 8203, Institut Gustave Roussy et Université Paris-Sud, France, 4Electrical and Computer Engineering, Texas Tech University, USA, 5Université d'Evry-Val d'Essone, France, 6Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Dept. of Pediatrics, Oregon Health & Science University, Portland, OR, USA; Children’s Cancer Therapy Development Institute, USA, 7Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, USA, 8Department of Neurosurgery, The First Affiliated Hospital of Soochow, China, 9Departments of Oncology and Pathology, Johns Hopkins University, USA, 10National Cancer Institute, USA, 11Department of Pediatric Oncology, Hematology and Neuro-Oncology Research Group Cancer Center Amsterdam, VU University Medical Center, The Netherlands, 12Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, USA, 13Dept. of Paediatric Laboratory Medicine, University of Toronto; Scientist, Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Canada, 14Departement de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, Université Paris-Sud, France, 15These authors contributed equally to this work, -, 16These authors contributed equally to this work, -
BI-03 DLX homeobox genes regulate neuronal vs oligodendroglial cell fate decisions: potential relevance to pediatric glioneuronal tumors and high grade gliomas
Jamie Zagozewski1, Sara Japoni1, Qiang Jiang1, Frank van Landeghem1, Paolo Nozza2, Alessandro Raso2, David Eisenstat*1
1University of Alberta, Canada, 2Instituto Giannina Gaslini, Italy
PM-04 Decoding the cellular heterogeneity of pediatric high grade glioma
Kwanha Yu*1, Jeffrey Carlson1, CC John Lin1, Wendy Zhu1, Nabil Ahmed2, Xiao-nan Li2, Carrie Mohila2, Michelle Monje3, Akash J Patel2, Benjamin Deneen1
1Baylor College of Medicine, USA, 2Texas Children's Hospital, USA, 3Stanford University, USA
HG-13 SOX9 as a down-stream target in RAS/MEK-driven pediatric glioma
Hanna Sabelstrom*1, Rahul Jandial2, Ksenya Shchors1,5, Selma Masic1, Allen Ho3, Scott Vandenberg4, Theodore P. Nicolaides1, Kim Nguyen1, Stanislava Yakovenko1, Michael D. Prados1, C. David James1, Mitchel S. Berger1, Gerard I. Evan1, Evan Y. Snyder3, William A. Weiss1, Anders I. Persson1
1University of California, San Francisco, USA, 2City of Hope Cancer Center & Beckman Research Institute, USA, 3Sanford-Burnham Institute for Medical Research, USA, 4University of California, San Diego, USA, 5Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
SC-02 Modeling pediatric GBM using neural stem cell-derived tumors with divergent behavior
Olle R Lindberg*, Andrew McKinney, Jane R Engler, Joanna J Phillips
University of California, San Francisco (UCSF), USA