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Session 1 - Featured Abstract Presentations
Thursday, May 7, 8:25am - 9:25am

MODERATORS: Suzanne Baker, David Eisenstat

 


AT-03 Atypical Teratoid/Rhabdoid Tumour is a genetically homogeneous but epigenetically heterogeneous disease that is defined by subgroup specific super-enhancers
Pascal Johann1,2, Serap Erkek1, Marc Zapatka1, Kornelius Kerl1,3, Ivo Buchhalter1, Volker Hovestadt1, Andrey Korshunov4, Marina Rhyzova5, David T.W. Jones1, Paul A. Northcott1, Michael C. Frühwald6, Martin Hasselblatt7, Amar Gajjar8, Stefan M. Pfister1,2, Marcel Kool*1
1German Cancer Research Center, Germany, 2Department of Pediatric Hematology and Oncology, University Hospital, Germany, 3Department of Pediatric Hematology and Oncology, University Hospital, Germany, 4epartment of Neuropathology, University Hospital, Germany, 5NN Burdenko Neurosurgical Insitute, Russia, 6Swabian Childrens’ Cancer Center, Germany, 7Institute of Neuropathology, Germany, 8St Jude Children's Research Hospital, USA
BT-05 Functional diversity and co-operativity of subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells 
Mara Vinci*1, Anna Burford1, Katy Taylor1, Valeria Molinari1, Sergey Popov1, Wendy Ingram2, Andrew Moore2, Michelle Monje3, Marta Alonso4, Jane Pears5, Natacha Entz-Werle6, Carmen de Torres7, Ofelia Cruz7, Jaume Mora7, Angel Montero Carcaboso7, Alan Mackay1, Chris Jones1
1Institute of Cancer Research, UK, 2Queensland Childrens Medical Research Institute, Australia, 3Stanford University, USA, 4University Hospital of Navarra, Spain, 5Our Lady's Children's Hospital, Ireland, 6CHRU Hautepierre, France, 7Hospital San Joan de Deu, Spain
GE-09 Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated malignant brain tumors in children
Adam Shlien1,2, Brittany B. Campbell*1,3, Richard de Borja1, Ludmil B. Alexandrov4, Diana M. Merino1, Marc Remke3, Doua Bakry5, Peter Dirks3,6, Annie Huang3,5, Richard G. Grundy9, Carol Durno7,13, Melyssa Aronson7, Michael D. Taylor3,6, Zachary F. Pursell8, Christopher E. Pearson1,10, David Malkin1,5, Eric Bouffet3,5, Cynthia Hawkins3,11, Peter J. Campbell4,12, Uri Tabori1,3
1Program in Genetics and Genome Biology, The Hospital for Sick Children, Canada, 2Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Canada, 3The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Canada, 4Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, UK, 5Division of Hematology/Oncology, The Hospital for Sick Children, Canada, 6Division of Neurosurgery, The Hospital for Sick Children, Canada, 7The Familial Gastrointestinal Cancer Registry at the Zane Cohen Centre for Digestive Disease, Mount Sinai Hospital, Canada, 8Department of Biochemistry & Molecular Biology, Tulane Cancer Center, Tulane University, School of Medicine, USA, 9Children’s Brain Tumour Research Centre, University of Nottingham, UK, 10Department of Molecular Genetics, University of Toronto, Canada, 11Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada, 12Department of Haematology, University of Cambridge, UK, 13Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Canada
HG-04 Neuronal activity-regulated secretion of neuroligin-3 promotes glioma growth
Humsa Venkatesh1, Tessa Johung1, Viola Caretti1, Alyssa Noll1, Hannes Vogel1, Markus Bredel2, Parag Mallick1, Michelle Monje*1
1Stanford University, USA, 2University of Alabama, USA