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Programme  Titles  Presenters  Topics 
ATRT
Atypical Teratoid/Rhabdoid Tumour is a genetically homogeneous but epigenetically heterogeneous disease that is defined by subgroup specific super-enhancers
Pascal Johann, Serap Erkek, Marc Zapatka, Kornelius Kerl, Ivo Buchhalter, Volker Hovestadt, Andrey Korshunov, Marina Rhyzova, David T.W. Jones, Paul A. Northcott, Michael C. Frühwald, Martin Hasselblatt, Amar Gajjar, Stefan M. Pfister, Marcel Kool*
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
Successful treatment of ATRT patients without adjuvant radiation: a multi institutional Canadian experience
Dennis Ku*, Lucie Lafay-Cousin, Chris Fryer, Juliette Hukin, Doug Strother, Annie Huang, Eric Bouffet
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Targeting mTOR downstream of LIN28 in Atypical Teratoid Rhabdoid Tumors promotes apoptosis and suppresses tumorigenicity
Jeffrey Rubens*, Antoinette Price, Charles Eberhart, Eric Raabe
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Targeting Myc driven transcriptional output in atypical teratoid rhabdoid tumor
Irina Alimova*, Sujatha Venkataraman, Angela Pierce, Andrea Greisinger, Diane Birks, Ilango Balakrishnan, Nicholas Foreman, Rajeev Vibhakar
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
The Hippo pathway activity in AT/RT
Mario Suzuki*, Akihide Kondo, Ikuko Ogino, Hajime Arai
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Therapeutic targeting of INI1 deficiency in pediatric ATRT: a pre-clinical study utilizing patient derived orthotopic xenograft (PDOX) models
Holly Lindsay*, Mari Kogiso, Lin Qi, Jeffrey Murray, Laszlo Perlaky, Jack Su, Patricia Baxter, Adekunle Adesina, Donald Parsons, Murali Chintagumpala, Xiao-Nan Li
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
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Basic Biology
4EBP1 participates in cisplatin resistance of human glioma cells through PI3K/AKT/mTOR pathway
Li Bie*, Cong Hua, Lei Liu, Hongyan Yuan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Disruption of perivascular astrocytic foot processes characterizes MRI enhancement in pediatric brain tumors
Christopher Hong, Martin Piazza*, Winson Ho, Zhengping Zhuang
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
DLX homeobox genes regulate neuronal vs oligodendroglial cell fate decisions: potential relevance to pediatric glioneuronal tumors and high grade gliomas
Jamie Zagozewski, Sara Japoni, Qiang Jiang, Frank van Landeghem, Paolo Nozza, Alessandro Raso, David Eisenstat*
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
PID1 is a chemotherapy sensitizer and candidate tumor suppressor in medulloblastoma
Jingying Xu, Xiuhai Ren, Gregory M Shackleford, Rex Moats, Anat Erdreich-Epstein*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
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Brainstem Tumors
A standardized autopsy procurement allows for the comprehensive study of DIPG biology
Madhuri Kambhampati, Jenifer Perez, Sridevi Yadavilli, Amanda Saratsis, Ashley Hill, Cheng-Ying Ho, Eshini Panditharatna, Melissa Markel, Roger Packer, Javad Nazarian*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Autopsy derived orthotopic xenograft (ADOX) mouse models for terminal pediatric brain tumors
Qi Li, Patricia Baster, Mari Kogiso, Yuchen Du, Holly Lindsay, Zhigang Liu, Xiumei Zhao, Jack Su, Adekunle Adesina, Andrew Walter, Jeffrey Murray, Rene McNall-Knapp, Javad Nazarian, Will Parsons, Murali Chintagumpala, Susan Blaney, Xiao-Nan Li*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Functional diversity and co-operativity of subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells 
Mara Vinci*, Anna Burford, Katy Taylor, Valeria Molinari, Sergey Popov, Wendy Ingram, Andrew Moore, Michelle Monje, Marta Alonso, Jane Pears, Natacha Entz-Werle, Carmen de Torres, Ofelia Cruz, Jaume Mora, Angel Montero Carcaboso, Alan Mackay, Chris Jones
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
Functionally-defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso, Yujie Tang*, Nathalene Truffaux, Noah E. Berlow, Lining Liu, Marie-Anne Debily, Michael J. Quist, Lara Davis, Elaine C. Huang, Pamelyn J. Woo, Anitha Ponnuswami, Spenser Chen, Tessa Johung, Wenchao Sun, Mari Kogiso, Yuchen Du, Qi Lin, Yulun Huang, Marianne Hutt-Cabezas, Katherine E. Warren, Ludivine Le Dret, Paul S. Meltzer, Hua Mao, Martha Quezado, Dannis G. van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N. Svalina, Nicholas Wang, Cynthia Hawkins, Eric Raabe, Esther Hulleman, Paul T. Spellman, Xiao-Nan Li, Charles Keller, Ranadip Pal, Jacques Grill, Michelle Monje
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Measuring tumor metabolism in diffuse intrinsic pontine gliomas (DIPG) using hyperpolarized carbon-13 MR spectroscopic imaging
Ilwoo Park*, Rintaro Hashizume, Xiaodong Yang, Peder Larson, C. David James, Daniel Vigneron, Sabine Mueller, Sarah Nelson
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
PLK1 as a potential therapeutic target for DIPG
Vladimir Amani*, Sujatha Venkataraman, Eric Prince, Diane Birks, Ilango Balakrishnan, Andrew Donson, Andrea Griesinger, Peter Harris, Nicholas Foreman, Rajeev Vibhakar
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Targeted inhbition of histone demethylase activity for the treatment of pediatric brainstem gliomas
Noemi Ander, Robin Lerner, Xi Huang, Maxwell Tom, Vy Ngo, David Solomon, Sabine Mueller, Pamela Paris, Zhiguo Zhang, Nalin Gupta, Todd Waldman, Stewart Goldman, David James, Rintaro Hashizume*
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Tenascin-C: A novel therapeutic target in pediatric brainstem glioma
Amanda Saratsis*, Madhuri Kambhampati, Jordan Hall, Mojca Stampar, Guifa Xi, Eric Raabe, Roger Packer, Javad Nazarian
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Trilexium inhibits the expression of t-NOX and is a novel, potentially potent therapy for Diffuse Intrinsic Pontine Gliomas
Anne Kankean*, Anahid Ehteda, Arjanna Chitranjan, Maria Tsoli, Eleanor Ager, David Ziegler
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
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Ependymoma
Activation of the IL6/STAT3 pathway in childhood ependymoma is associated with a pro-inflammatory tumor microenvironment and a poor prognosis
Andrea Griesinger*, Rebecca Josephson, Andrew Donson, Jean Mulcahy Levy, Vladimir Amani, Diane Birks, Lindsey Hoffman, Rajeev Vibhakar, Michael Handler, Nicholas Foreman
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Heterogeneity of RelA protein expression in paediatric ependymoma
Tim Ritzmann*, Hazel Rogers, Jennifer Ward, Richard Grundy
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Molecular classification of ependymal tumors across all CNS compartments, histopathological grades and age groups
Kristian W. Pajtler, Hendrik Witt, Martin Sill, David Jones, Volker Hovestadt, Pascal Johann, Juri Reimand, Peter Lichter, Michael D. Taylor, Richard Gilbertson, David W. Ellison, Kenneth Aldape, Andrey Korshunov, Stefan M. Pfister, Marcel Kool*
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Molecular classification of ependymomas in  a Japanese cohort
Kohei Fukuoka*, Shintaro Fukushima, Satoshi Yamashita, Tomoko Shofuda, Taishi Nakamura, Kai Yamasaki, Hirokazu Takami, Yuko Matsushita, Toshikazu Ushijima, Yoshitaka Narita, Yonehiro Kanemura, Mami Yamasaki, Soichiro Shibui, Hajime Arai, Ryo Nishikawa, Koichi Ichimura
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Posterior fossa ependymoma subgroups have distinct therapeutic and prognostic implications
Vijay Ramaswamy*, Stephen Mack, Michael Taylor, For the GENE consortium
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
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Genetics/Epigenetics
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated malignant brain tumors in children
Adam Shlien, Brittany B. Campbell*, Richard de Borja, Ludmil B. Alexandrov, Diana M. Merino, Marc Remke, Doua Bakry, Peter Dirks, Annie Huang, Richard G. Grundy, Carol Durno, Melyssa Aronson, Michael D. Taylor, Zachary F. Pursell, Christopher E. Pearson, David Malkin, Eric Bouffet, Cynthia Hawkins, Peter J. Campbell, Uri Tabori
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
Comprehensive genomic profiling (CGP) of pediatric gliomas reveals a high frequency of clinically relevant genomic alterations (CRGA) associated with benefit from targeted therapy
Zachary R Chalmers*, Siraj M Ali, Garrett M Frampton, Juliann Chmielecki, Norma A Palma, Julia A Elvin, Adrienne Johnson, Roman Yelensky, Jeffery S Ross, Phillip J Stephens, Vincent A Miller, Angela J Waanders, John Crawford
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
DNA methylation in medulloblastoma and molecular diagnostics of brain tumors
Volker Hovestadt*, David Capper, Martin Sill, Simone Picelli, Wei Wang, Paul A. Northcott, Marcel Kool, Marc Zapatka, Bernhard Radlwimmer, Andreas von Deimling, Stefan M. Pfister, Peter Lichter, David T. W. Jones
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglial-like leptomeningeal tumors
Matthew J Schniederjan*, Fausto J Rodriguez, Theo Nicolaides, Tarik Tihan, Peter C Burger, Arie Perry
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Identification of targetable mutations in rare pediatric brain tumors by clinical whole exome sequencing
Frank Y. Lin*, Abhishek Bavle, David Wheeler, Richard Gibbs, Sandi Lam, Jack Su, Murali Chintagumpala, Adekunle Adesina, Angshumoy Roy, Sharon E. Plon, D. Williams Parsons
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
IDH1-mutated pituitary adenoma challenges traditional characterization of Maffucci syndrome
Christopher Hong*, Shuyu Hao, Jie Feng, Chunzhang Yang, Prashant Chittiboina, Junting Zhang, Zhengping Zhuang
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Impact of H3.3K27M mutation on cancer epigenome
Dong Fang, Zhiguo Zhang*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Paradoxical genetic and epidemiologic relationships between cancer and autism
Rohini Singh*, Benjamin Darbro, Alexander Bassuk
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Study of epigenetic deregulation of a novel deubiquitylase in medulloblastoma
Rashieda Hatcher*, Chandra Das, Jason Fangusaro, Veena Rajaram, Rishi Lulla, Stewart Goldman, Soumen Khatua, Gianluca Sbardella, Vidya Gopalakrishnan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
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Germ Cell Tumors
CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways
Torsten Pietsch*, Barbara Steiger, Dorota Denkhaus, Christian Vokuhl, Ivo Leuschner
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Elucidation of pathogenesis in intracranial germ cell tumors based on a genome-wide methylation study
Shintaro Fukushima, Satoshi Yamashita, Hirokazu Takami, Kohei Fukuoka, Yoshitaka Narita, Toshikazu Ushijima, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura*, Intracranial Germ Cell Tumors Genome Analysis Consortium
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Intracranial nongerminomatous germ cell tumors: treatment strategies and outcomes
Brandon Imber*, Steve Braunstein, Anuradha Banerjee, Tarik Tihan, Andrew Bollen, Daphne Haas-Kogan, Sabine Mueller
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Preliminary results of a feasibility pilot study of “Gempox” (gemcitabine, oxaliplatin, and paclitaxel) in pediatric and adult patients with refractory or recurrent central nervous system (CNS) germ cell tumors (GCT): the International CNS GCT Consortium Trial, CNS GCT- 4
Jonathan Finlay*, Kelly Haley, Girish Dhall, Diana Osorio, Sharon Gardner, Jeffrey Allen, Jeffrey Leonard
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
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High Grade Glioma
A novel mouse model of young adult glioblastoma: In vivo expression of mutated IDH1 (R132H) gene using the Sleeping Beauty Transposase System
Felipe J. Nunez*, Flor M. Mendez, Carl Koschmann, Alexandra Calinescu, Marta Dzaman, Pedro R. Lowenstein, Maria G. Castro
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A role of spindle cells in glioblastoma growth
Shoko Yamada, Lue Sun, Shokei Yamada*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
ATRX loss promotes tumor growth and impairs genetic stability in glioblastoma
Carl Koschmann*, Alexandra Calinescu, Daniel Thomas, Felipe J. Nunez, Marta Dzaman, Johnny Krasinkiewicz, Neha Kamran, Rosie Lemons, Flor Mendez, Youping Li, David Ferguson, Vera Gorbunova, Soyeon Roh, Lili Zhao, Alan Meeker, Pedro R. Lowenstein, Maria G. Castro
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Clinical, radiographic, and histologic characteristics of long-term survivors of diffuse intrinsic pontine glioma: a report from The International DIPG Registry
Lindsey M. Hoffman*, Ute Bartels, Lili Miles, Cynthia Hawkins, Stewart Goldman, Sarah Leary, Tim Hassal, Jane Minturn, Roger Packer, Nicholas Foreman, Kathy Warren, Alberto Broniscer, Emmett Broxon, Chie-Schin Shih, James Leach, Blaise Jones, Josh Baugh, Brooklyn Hacker, Brianna Lerme, Chris Jones, Sharon Savage, Jenavieve Kirkendall, Renee Doughman, Matt Wollman, Linwood Millett, Rachel O'Keefe, Eric Bouffet, Dannis G. van Vuurden, Maryam Fouladi
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Daam2 promotes tumor proliferation and migration in glioblastoma
Wenyi Zhu*, Hyun-Kyoung Lee, Joseph Loturco, Carrie Mohila, Benjamin Deneen
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Detection of K27M mutant pediatric glioblastomas by immunohistochemistry
Sriram Venneti*, Mariarita Santi, Michelle Madden Felicella, Dmitry Yarilin, Joanna Phillips, Lisa Sullivan, Daniel Martinez, Arie Perry, Peter Lewis, Craig Thompson, Alexander Judkins
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Disrupting the epigenetic modifier HMGA2 in DIPG and GBM inhibits tumor invasion, growth and tumorigenicity
Harpreet Kaur*, Marianne Hütt-Cabezas, Isabella Taylor, Melanie Weingart, Fausto Rodriguez, Charles Eberhart, Eric Raabe
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Hypoxia pathway driven by HIF-1alpha are predominantly involved in pediatric high grade glioma and represent promising therapeutic targets
Christelle Lasthaus, Marie Litzler, Cyril Bour, Dominique Guenot, Natacha Entz-Werlé*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Integrative molecular meta-analysis of 700 pediatric high grade glioma and DIPG defines widespread inter- and intra-tumoral heterogeneity
Alan Mackay*, Mara Vinci, Anna Burford, Lynn Bjerke, Katy Taylor, Meera Nandhabalan, Lynley Marshall, Valeria Molinari, Sergey Popov, Wendy Ingram, Andrew Moore, Saoussen Trabelsi, Dorra Hmida, Kun Mu, Lucas Bidinotto, Rui Reis, HK Ng, Andre von Bueren, Michael Baudis, Chris Jones
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Infantile glioblastoma with sarcomatous histology driven by ETV6:NTRK3 fusions are sensitive to Trk inhibition by PHA-848125
Diana Carvalho*, Katy Taylor, Anna Burford, Ilona Nowak, Alan Mackay, Mara Vinci, Lynn Bjerke, Valeria Molinari, Meera Nandhabalan, Wendy Ingram, Alexa Jury, Rachael Natrajan, David Jones, Stefan Pfister, Ludmila Shats, Andrew Moore, Thomas Jacques, Sergey Popov, Chris Jones
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Inhibition of epigenetic regulation as a therapy for pediatric high grade glioma
Stephen Dombrowski*, Thamara Abou-Antoun, Stephen Mack, Xiao-Nan Li, Peter Houghton, Darell Bigner, Jeremy Rich, Violette Recinos
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
LIN28 and MYC expressing pediatric glioblastomas are sensitive to inhibitors of glutamine metabolism
Isabella Taylor*, Sama Ahsan, Melanie Weingart, Charles Eberhart, Eric Raabe
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
MGMT promoter methylation status and miRNA-181 family expression as prognostic markers in glioblastoma patients
Li Bie*, Cong Hua, Gang Zhao, Yuanqian Li
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Neuronal activity-regulated secretion of neuroligin-3 promotes glioma growth
Humsa Venkatesh, Tessa Johung, Viola Caretti, Alyssa Noll, Hannes Vogel, Markus Bredel, Parag Mallick, Michelle Monje*
Thursday, May 7:  Session 1 - Featured Abstract Presentations  -  8:25am - 9:25am
SOX9 as a down-stream target in RAS/MEK-driven pediatric glioma
Hanna Sabelstrom*, Rahul Jandial, Ksenya Shchors, Selma Masic, Allen Ho, Scott Vandenberg, Theodore P. Nicolaides, Kim Nguyen, Stanislava Yakovenko, Michael D. Prados, C. David James, Mitchel S. Berger, Gerard I. Evan, Evan Y. Snyder, William A. Weiss, Anders I. Persson
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Targeted next generation sequencing in malignant supratentorial pediatric brain tumors reveals actionable mutations
Bonnie Cole, Colin Pritchard, Maia Anderson, Sarah Leary*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The anti-apoptotic protein ARC is over-expressed in malignant glioma and correlates with patient outcome
Anne Kankean*, Maria Tsoli, Joanna Tsang, Arjanna Chitranjan, Sanaz Maleki, Kerrie McDonald, David Ziegler
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The histone deacetylase inhibitor PCI-24781 shows antiproliferative, pro-apoptotic and radiosensitizing effects on pediatric glioblastoma cell-lines
Pamela Viani Andrade, Augusto Faria Andrade, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
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Immunology/Immunotherapy
A bioinformatics evaluation of tumor-associated macrophages across 2 brain tumor types
Wan-Yee Teo*, Sekar Karthik, Seshachalam Veerabrahma Pratap, Xiaonan Li, Jianhe Shen, M. Tarek Elghetany, Kam-Man Hui, Ching C Lau
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A scFv-based CAR to redirect T cells to IL13Rα2-positive pediatric glioma
Giedre Krenciute*, Simone Krebs, David Torres, Maciej Lesniak, Irina Balyasnikova, Stephen Gottschalk
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Anti-tumor effect of trastuzumab, GM-CSF and IL-2 combinatorial therapy in pediatric ependymoma
Andrew Donson*, Andrea Griesinger, Diane Birks, Vladimir Amani, Jean Mulcahy-Levy, Michael Handler, Kathleen Dorris, Nicholas Foreman
Friday, May 8:  Session 8 - Ependymoma  -  8:20am - 9:00am
Anti-tumor efficacy of adoptive cellular therapy is significantly increased by hematopoietic stem cells
Catherine Flores*, Christina Pham, Tyler Wildes, Rebecca Abraham, Jeffrey Drake, Duane Mitchell
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Delta-24-RDG as an alternative therapeutic tool for pHGG/DIPG
Naiara Martinez-Velez*, Enric Xipell, Hong Jiang, Cande Gómez-Manzano, Juan Fueyo, Marie-Pierre Junier, Hervé Chneiweiss, Elias El Habr, Michelle Monje, Oren Becher, Marta M Alonso
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effects of T-cell TGF-β signaling abrogation on survival in pediatric glioma
Joshua Breunig*, Moise Danielpour, Rachelle Levy, Marina Dutra-Clarke
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
GBM-associated exosome-pulsed autologous DC vaccine (DC-Vex®) induces D-2 apoptotic-stage and bystander killing-effect in GBM of the mesenchymal type
John Giannios*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Immunologic targeting of medulloblastoma subtypes using developmentally regulated antigens
Christina Pham*, Catherine Flores, Yanxin Pei, Robert Wechsler-Reya, Duane Mitchell
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Inflammation driver, NF-kB, is associated with poor outcome Group A ependymoma and regulates a key immune suppressive signaling pathway involved in the tumor microenvironment
Andrea Griesinger*, Andrew Donson, Jean Mulcahy Levy, Vladimir Amani, Diane Birks, Rajeev Vibhakar, Michael Handler, Nicholas Foreman
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Molecular engineering of amplified tumor RNA-pulsed dendritic cells in adoptive cellular therapy targeting medulloblastoma and glioblastoma
Oleg Yegorov*, Jeffery Drake, Duane Mitchell
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Multispecific CAR T cells for the treatment of high grade glioma
Kevin Bielamowicz*, Kristen Fousek, Tiara Byrd, Kevin Chow, Zhongzhen Yi, Simone Krebs, Gianpietro Dotti, Stephen Gottschalk, Meena Hegde, Nabil Ahmed
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
NK cell immunotherapy for pediatric brain tumors: overcoming resistance to expand therapeutic success
William Brugmann*, Alvaro Laureano, Keith Michel, Rong-Hua Tao, Bridget Kennis, Srinivas Somanchi, Cecele Denman, King Ching Ho, Lucia Silla, Harjeet Singh, Helen Huls, David Sandberg, Dean Lee, Jim Bankson, Annie Huang, Laurence Cooper, Vidya Gopalakrishnan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
RNA nanoparticle vaccines re-program host immunity in favor of enhanced effector responses against intracranial malignancies
Elias Sayour, Gabriel De Leon, Christina Pham, Catherine Flores, Luis Sanchez-Perez, Duane Mitchell*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Serial metabolism of diffuse intrinsic pontine glioma treated with peptide based vaccine therapy
Ashok Panigrahy*, Brenda Kurland, Rafael Ceschin, Shira Abberbock, Hideho Okada, Regina Jakacki, Ian Pollack, Stefan Bluml
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
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Low Grade Glioma
BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma
Matthew Mistry*, Nataliya Zhukova, Daniele Merico, Patricia Rakopoulos, Rahul Krishnatry, Mary Shago, Jim Stavropoulos, Jason Pole, Peter Ray, Marc Remke, Pawel Buczkowicz, Vijay Ramaswamy, Adam Shlien, James Rutka, Peter Dirks, Michael Taylor, David Malkin, Eric Bouffet, Cynthia Hawkins, Uri Tabori
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Challenges in the management of hypothalamic juvenile pilocytic astrocytoma
William Gump*, Ian Mutchnick, Jennifer Elster, Kanyalakshmi Ayyanar
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effects of TORC1/2 inhibitor MLN0128 alone and in combination with MEK inhibition in BRAF mutated glioma cells
Sabine Mueller*, Rogier Dik, Xiaodong Yang, Ola Aleksandra, Clay Gustafson, Steve DuBois, William Weiss, Angela Waanders, Adam Resnick, Daphne Haas-Kogan
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Mosaic genetic progression models of low grade pediatric brain tumors reveal unique features of tumor evolution
C. Danielle Antonuk, Rachelle Levy, Jessica Molina, Moise Danielpour, Aslam Akhtar, Joshua Breunig*
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Notch signaling activation in pediatric low-grade astrocytoma
William D. Brandt, Karisa C. Schreck, Eli E. Bar, Isabella Taylor, Luigi Marchionni, Eric Raabe, Charles G. Eberhart, Fausto J. Rodriguez*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pediatric grade II glioma molecular screening in adolescents and young adults
Irene Ollivier, Christelle Lasthaus, Marie Litzler, Dominique Guenot, Natacha Entz-Werlé*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Radiation therapy is associated with increased late mortality in long-term adult survivors of childhood low grade glioma: A population based study
Rahul Krishnatry*, Nataliya Zhukova, Ana Guerreiro Stucklin, Jason Pole, Matthew Mistry, Vijay Ramaswamy, Ute Bartels, Annie Huang, Normand Laperriere, Peter Dirks, Shayna Zelcer, Mariana Silva, Donna L Johnston, Katrin Scheinemann, Cynthia Hawkins, Pratiti Bandopadhayay, Mark W Kieran, Peter E Manley, Eric Bouffet, Uri Tabori
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
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Medulloblastomas/PNETs
WIP1 augments sonic hedgehog (SHH) signaling and is a target in SHH medulloblastomas
Juhyun Lee, Meghan Buss, Jing Wen, Marc Remke, Michael Taylor, Robert Castellino*
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
Activated Wnt signaling targets Sox2+ treatment-refractory Shh-dependent medulloblastoma stem cells
Branavan Manoranjan*, Chitra Venugopal, Sujeivan Mahendram, Steven Moreira, Robin Hallett, Thusyanth Vijayakumar, David Bakhshinyan, Nicole McFarlane, John Hassell, Bradley Doble, Sheila Singh
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Aggressive medulloblastoma subverts the photoreceptor specific transcription factor NRL
Alexandra Garancher, Morgane Morabito, Nathalie Rocques, Magalie Larcher, Catherine Micquel, Stéphanie Puget, François Doz, Olivier Delattre, Olivier Ayrault, Alain Eychène, Franck Bourdeaut, Celio Pouponnot*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Boost volume effects on incidental hippocampal dose in pediatric medulloblastoma
Palak Kundu*, Iris Gibbs
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in myc-driven medulloblastoma
Eric Prince*, Monil Shah, Sujatha Venkataraman, Ilango Balakrishnan, Irina Alimova, Peter Harris, Diane Birks, Andrew Donson, Michael Taylor, Michael Handler, Nicholas Foreman, Rajeev Vibhakar
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Co-inhibition of the Sonic hedgehog and CXCR4 pathways uniquely blocks tumor initiating cell function in medulloblastoma
Stacey Ward*, Joshua Rubin
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
Discovering the treatment refractory BTIC population in group 3 medulloblastoma
David Bakhshinyan*, Thusyanth Vijayakumar, Neha Garg, Branavan Manoranjan, Nicole McFarlane, Chitra Venugopal, Sheila Singh
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Dissecting the role of epigenetic modulators in Shh-driven medulloblastoma
Tara Dobson*, Rong-Hua Tao, Shavali Shaik, Pete Taylor, Rashieda Hatcher, Ellen Busschers, Soumen Khatua, Stewart Goldman, Rishi Lulla, Veena Rajaram, Tobey MacDonald, Jason Fangusaro, Vidya Gopalakrishnan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Evaluating the oncogenic potential of TSC1/2 mutations and efficacy of MTOR inhibitors in high risk pediatric medulloblastoma
Jacob Henderson*, Jacob Wagner, Monika Davare
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Expression of CRMP1 inhibits cell proliferation of medulloblastoma and is regulated by HMGA1
Ho-Keung Ng*, Ka Wai Kay Li, Yan Qi, Xia Tian, Yu Yao, Liangfu Zhou, Kin-Mang Lau
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Feasibility of vorinostat combined with isotretinoin and chemotherapy for young children with newly diagnosed embryonal brain tumors: A Pediatric Brain Tumor Consortium Study
Sarah Leary*, Lindsay Kilburn, J. Russell Geyer, James M. Olson, Tobey MacDonald, David Ellison, Mehmet Kocak, Arzu Onar, Ralph Ermoian, Tina Young Poussaint, James M. Boyett, Larry Kun, Maryam Fouladi
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Functional characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes
Lisa Liang*, Christopher Aiken, Robyn McClelland, Ludivine Morrison, Marc Remke, Vijay Ramaswamy, Marc Del Bigio, Michael Taylor, Tamra Werbowetski-Ogilvie
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Genome-wide copy number analysis, neuropathological classification and analysis of hedgehog activation: Histology reflects genetics and biology in medulloblastomas of young children
Elena Kapitza, Dorota Denkhaus, Anja zur Mühlen, Stefan Rutkowski, Torsten Pietsch*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
GSK-3 promotes proliferation during postnatal cerebellar development and may be targeted in medulloblastoma therapy
Jennifer Ocasio*, Timothy Gershon
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
HDAC and PI3K antagonists cooperate to inhibit growth of MYC-driven medulloblastoma
Kun-Wei Liu*, Yanxin Pei, Robert Wechsler-Reya
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Impact of molecular sub-type and craniospinal irradiation (CSI) dose on relapse of medulloblastoma
Ange Wang*, Sonia Partap, Kristen Yeom, Mesha Martinez, Hannes Vogel, Sarah Donaldson, Paul Fisher, Sebastien Perreault, Yoon-Jae Cho, Iris Gibbs
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Induced cisplatin resistance in medulloblastomas
Michael Feldman*, Winson Ho, John Heiss, Matthew Hall, Zhenping Zhuang
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors
Marc Remke*, Florence Cavalli, A. Sorana Morrissy, Vijay Ramaswamy, David Jones, Roger Packer, Eric Bouffet, Gary Bader, Stefan Pfister, Nada Jabado, Marco Marra, Michael Taylor
Thursday, May 7:  Session 7 - Medulloblastoma 1  -  4:40pm - 5:10pm
Metachronous supratentorial intracranial malignant tumors in two pediatric patients with infratentorial medulloblastoma on hormone therapy
Augustus Perez*, James Shiflett, Betty Herrington
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Medulloblastoma subtypes specify inter-tumoral vascular blood brain barrier heterogeneity
Timothy Phoenix*, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Lilian Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, Richard Gilbertson
Thursday, May 7:  Session 7 - Medulloblastoma 1  -  4:40pm - 5:10pm
MicroRNA expression patterns in tissue and cerebrospinal fluid aid in molecular classification of pediatric medulloblastoma
Rishi Lulla*, Joseph Laskowski, Yingtao Bi, Stewart Goldman, Jason Fangusaro, Vidya Gopalakrishnan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Molecular (re-)classification of CNS-primitive neuroectodermal tumors
Marcel Kool*, Dominik Sturm, Volker Hovestadt, David Jones, Paul Northcott, Peter Lichter, Andrey Korshunov, Stefan Pfister
Thursday, May 7:  Session 7 - Medulloblastoma 1  -  4:40pm - 5:10pm
Molecular subgroups of medulloblastoma identification using non-invasive magnetic resonance spectroscopy
Ashley Margol*, Stefan Bluml, Richard Sposto, Rebekah Kennedy, Nathan Robison, Marzieh Vali, Long Hung, Sakunthala Muthugounder, Jonathan Finlay, Anat Erdreich-Epstein, Floyd Gilles, Alexander Judkins, Mark Krieger, Girish Dhall, Marvin Nelson, Shahab Asgharzadeh
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Notch1 promotes MYC medulloblastoma metastasis, initiation and maintenance
Suzana Kahn*, Ryan Nitta, Kevin Wang, Sharareh Gholamin, Tej Azad, Michael Zhang, Yoon-Jae Cho, Michael Taylor, Siddhartha Mitra, Irving Weissman, Samuel Cheshier
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Novel candidate oncogenic drivers in pineoblastoma
Matija Snuderl*, Kasthuri Kannan, Olga Aminova, Igor Dolgalev, Adriana Heguy, Arline Faustin, David Zagzag, Sharon Gardner, Jeffrey Allen, Jeffrey Wisoff, David Capper, Volker Hovestadt, Sama Ahsan, Charles Eberhart, Stefan Pfister, David Jones, Matthias Karajannis
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Oncolytic picornavirus SVV-001 prolongs animal survival in a patient tumor-derived orthotopic xenograft mouse model of Group 3 supratentorial primitive neuroectodermal tumor
Zhigang Liu, Lin Qi, Xiu Mei Zhao, Yulun Huang, Mari Kogiso, Yuchen Du, Holly Lindsay, Patricia Baxter, Jack Su, Adekunle Adesina, Murali Chintagumpala, Xiao-Nan Li*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pathway analysis of a human neural stem cell model of aggressive medulloblastoma reveals CDK inhibition as a potential therapeutic modality
Allison Hanaford*, Tenley Archer, Pablo Tamayo, Scott Pomeroy, Charles Eberhart, Eric Raabe
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Pharmacological inhibition of MRK/ZAK kinase for the treatment of medulloblastoma
Rosamaria Ruggieri*, Daniel Markowitz, Caitlin Powell, Nhan Tran, Magimairajan Vanan, Mingzu He, Yousef Al Abed, Marc Symons
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Prognostic impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in medulloblastoma
Akihide Kondo*, Tomoko Kurimoto, Sachi Sakaguchi, Hajime Arai
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Primary Ewing sarcoma of the scalp with apparent epidural extension: case illustration
William Gump*, Robert Debski, Matthew Thompson, Kanyalakshmi Ayyanar
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Post-translational regulation of Atoh1: from cerebellar development to medulloblastoma formation
Sara Maria Cigna**, Antoine Forget*, Laure Bihannic, Marc Remke, Sandrine Humbert, Michael D. Taylor, Anna Lasorella, Olivier Ayrault
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Regulation of medulloblastoma formation by Gfi1 and Gfi1b
Catherine Lee*, Paul Northcott, Thomas Zichner, Jan Korbel, Stefan Pfister, Robert Wechsler-Reya
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
SILAC based quantitative proteomics of MYC-amplified medulloblastoma
Jerome Staal, Ling San Lau, Huizhen Zhang, Yetrib Hathout, Kristy Brown, Brian Rood*
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
Sonic hedgehog induces YB-1 in a YAP-dependent manner to regulate Igf2 expression and proliferation in cerebellar granule neuron progenitors and medulloblastoma cells
Abhinav Dey*, Mélanie Robitaille, Marc Remke, Caroline Maier, Anshu Malhotra, Alex Gregorieff, Jeffrey Wrana, Michael Taylor, Stéphane Angers, Anna Kenney
Friday, May 8:  Session 10 - Medulloblastoma II, Part 2  -  10:30am - 11:20am
Targeting medulloblastoma with a new small-molecule drug that inhibits MYC mediated translation
Bronwen Foreman*, Irina Alimova, Peter Harris, Ilango Balakrishnan, Eric Prince, Nicholas Foreman, Rajeev Vibhakar, Sujatha Venkataraman
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The critical role of Olig2-expressing progenitors in the initiation of G-protein mediated Sonic Hedgehog-driven medulloblastoma
Xuelian Lu, Richard Lu*
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Very encouraging long-term survival and neurocognitive outcome of young children treated for medulloblastoma with sequential high dose chemotherapy
Lucie Lafay-Cousin, Susan Chi, Amy Smith, Elizabeth Wells, Jennifer Madden, Ashley Margol, Vijay Ramaswamy, Emily Owen, Douglas Strother, Girish Dhall, Nicholas Foreman, Roger Packer, Eric Bouffet*
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
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Other
Characterization of infiltrating myeloid cells associated with xenografted gliomas in the rodent brain
Josh Morganti, Sharon Liu, Susanna Rosi, Nalin Gupta*
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
Distinct brain lineage and stromal gene expression patterns in WNT, SHH, Group 3 and Group 4 molecular subgroups of pediatric medulloblastoma
Achal Achrol, Tiffany Liu, Hannes Vogel, Steven Chang, Michael Edwards, Griffith Harsh, Debashis Sahoo*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Effectiveness of perfusion and diffusion imaging for grading pediatric brain tumors
Teresa Kelly*, Melissa Prah, Sachin Jogal, Mohit Maheshwari, Sean Lew, Kathleen Schmainda
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
H3.3-K27M is a negative prognostic marker in thalamic pediatric glioma
Scott Ryall*, Pawel Buczkowicz, Rahul Krishnatry, Anthony Arnoldo, Paul Steinbok, Uri Tabori, Cynthia Hawkins
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Implementation of next generation copy number and mutational analysis in routine neuropathology: molecular inversion profiling is a helpful tool in differential diagnostics and prognostification of pediatric brain tumors
Torsten Pietsch*, Marco Gessi, Anja zur Mühlen, Evelyn Dörner, Andy Last, Padma Sundar
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Multicentric primary central nervous system diffuse large b cell lymphoma in an inmunocompetent adolescent, case report
Jose Leon*, Rocio Cardenas, Marta Zapata, Liliana Velasco
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pediatric anaplastic meningioma: a case report successfully treated with combined chemotherapy for soft tissue sarcomas and radiotherapy.
Maurizio Lucchesi*, Sabrina Becciani, Anna Maria Buccoliero, Alessia Stival, Ludovica Facchini, Silvia Farina, Maurizio de Martino, Iacopo Sardi
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Primary central nervous system melanocytic lesions in childhood: experience at National Institute of Pediatrics in Mexico
Yahiel Osorio-Alamillo*, Marta Zapata-Tarres, Ana Niembro, Rodolfo Rodriguez-Jurado, Pedro Pasquel -García, Mauricio Rojas, Rolando Jimenez-Guerra, Leticia Munive, Patricia Herrera
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Primary central nervous system non hodgkin lymphoma in a pediatric patient without immunodeficiency related. case report and literature review
Marco R. Aguilar-Ortiz*, Rocío Cardenas-Cardós, Liliana Velasco-Hidalgo, Pedro-Mario Pasquel-García-Vázquez, Roberto Rivera-Luna, Alfonso Marhx-Bracho
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
When to biopsy a pineal region mass in children
Craig Erker*, Subramanian Subramanian, Teresa Kelly, Sachin Jogal
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
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Pediatric Brain Tumor Models
A humanized co-transplant xenograft mouse model, to study toxicity of drugs targeted against pediatric brain tumors
Sharareh Gholamin*, Suzana Assad Kahn, Rogelio Esparza, Gregor Hutter, Abdullah Feroze, Irving L. Weissman, Siddhartha S. Mitra, Samuel H. Cheshier
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
A piggyBac toolkit for rapid testing of putative pediatric GBM driver genes with extensions for investigating cells of recurrence
Joshua Breunig*, Rachelle Levy, C. Danielle Antonuk, Jessica Molina-Aravena, Marina Dutra-Clarke, Aslam Akhtar, Gi Bum Kim, Hannah Park, Moise Danielpour
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
An animal model of 17p deletion in medulloblastoma
John Peacock*, Anindya Bagchi, Sean Egan, Michael Taylor
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Bcl-xL dependence of neural progenitors may be exploited to improve medulloblastoma therapy
Katherine Veleta*, Andrew Crowther, Timothy Gershon
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Biological consequences of histone mutations in the mammalian brain
Jon Larson*, Lawryn Kasper, Helen Russell, Chunxu Qu, Xiaoyan Zhu, Peter McKinnon, Suzanne Baker
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
Conditional inactivation of Smarcb1 in P0 permissive mouse cells generates rhabdoid tumors in the peripheral nervous system and in the brain
Jeremie Vitte*, Fabrice Chareyre, Anat Stemmer-Rachamimov, Alexander Judkins, Marco Giovannini
Thursday, May 7:  Session 2 - ATRT  -  9:25am - 10:15am
Decoding the cellular heterogeneity of pediatric high grade glioma
Kwanha Yu*, Jeffrey Carlson, CC John Lin, Wendy Zhu, Nabil Ahmed, Xiao-nan Li, Carrie Mohila, Michelle Monje, Akash J Patel, Benjamin Deneen
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Development of a novel gene targeting and clone screening platform to engineer common pediatric glioma mutations into model cell lines
Nathan Fons*, Ranjini Sundaram, Ranjit Bindra
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Differential splicing of pyruvate kinase regulates progenitor cell cycle and medulloblastoma tumorigenesis
Katherine Tech*, Tia Fish, Andrew Crowther, Andrey Tikunov, Jeffrey Macdonald, Timothy Gershon
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Establishment and molecular characterization of patient-derived xenograft models of pediatric brain tumors
Sebastian Brabetz*, Huriye Seker-Cin, Susanne N. Gröbner, Volker Hovestadt, David T. W. Jones, Paul A. Northcott, Till Milde, Jessica M. Rusert, Kyle Pedro, Karina Bloom, Xiao-Nan Li, Robert J. Wechsler-Reya, James M. Olson, Stefan M. Pfister, Marcel Kool
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Genetically engineered mouse models of choroid plexus tumors
Jun Wang*, Diana Merino, Brian Murphy, Girish Dhall, Erin Kiehna, Alexander Judkins, David Ellison, Charles Eberhart, Scott Vandenberg, David Malkin, Richard Gilbertson, Martine Roussel, Robert Wechsler-Reya
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Notch and Shh signaling pathways converge on the primary cilium to promote choroid plexus tumor initiation from epithelial progenitors
Haotian Zhao*, Li Li, Katie Picotte, Jun Wang, Robert Wechsler-Reya, Jasmin Ohli, Ulrich Schüller
Thursday, May 7:  Session 6 - Germ Cell Tumors/Choroid Plexus Tumors  -  3:40pm - 4:40pm
Neural derivatives from human embryonic stem cells: a cellular system to study the role of Otx2 in medulloblastoma progression.
Ravinder Kaur*, Christopher Aiken, Ludivine Coudiere Morrison, Radhika Rao, Marc Del Bigio, Shravanti Rampalli, Tamra Werbowetski-Ogilvie
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
Tumor location remodels transcriptomic profiles in a pediatric medulloblastoma xenograft
Gregory Friedman*, Li Nan, Blake Moore, Tina Etminan, Brent Orr, Joseph Chewning, David Crossman, G. Yancey Gillespie
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Using a zebrafish pediatric brain tumor model for pre-clinical drug screening
Katarzyna Modzelewska*, Daniel Picard, Elena Boer, Rodney Miles, Randy Jensen, Theodore Pysher, Joshua Schiffman, Cicely Jette, Annie Huang, Rodney Stewart
Thursday, May 7:  Featured Poster Discussion: 5:30pm - 6:10pm
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Signaling
A role for NADPH oxidase 4-generated reactive oxygen species in Sonic hedgehog-driven proliferation of cerebellar granule neuron precursors
Chad Potts*, Rachel Rotenberry, Anna Kenney
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Feedback activation of EGFR via PTPN9 leads to glioma escape from BRAFV600E targeted therapy
Tsun-Wen Yao*, Jie Zhang, Michael Prados, William Weiss, David James, Theodore Nicolaides
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Role of mTOR signalling pathway in the pathogenesis of subependymal giant cell astrocytomas
Mehar Sharma*, Kalpana Kumari, Aanchal Kakkar, Chitra Sarkar, Vaishali Suri, Sarat Chandra
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The eEF2 kinase, a mediator of medulloblastoma adaptation to metabolic stress, supports fatty acid oxidation
Gabriel Leprivier*, Raffaele Teperino, Anders Kristensen, Marc Remke, Stefan Pfister, Michael D. Taylor, J. Andrew Pospisilik, Poul H. Sorensen
Friday, May 8:  Session 9 - Medulloblastoma II  -  9:00am - 10:10am
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Stem Cells
Modeling pediatric GBM using neural stem cell-derived tumors with divergent behavior
Olle R Lindberg*, Andrew McKinney, Jane R Engler, Joanna J Phillips
Thursday, May 7:  Session 3 - Brainstem Gliomas/High Grade Gliomas  -  10:35am - 12:05pm
Neural stem cell-mediated enzyme/prodrug therapy for medulloblastoma
Margarita Gutova, Diana Oganesyan, Silvia Tacheva Grigorova, Yanxin Pei, David Shahmanyan*, Zhongqi Li, Michael Barish, Karen Aboody, Robert Wechsler-Reya
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
RalA in biology and therapy of MPNST in correlation to cancer stem cells
Kaoru Terai, Emma Borrego-Diaz, Darren Lovick, Michael Salacz, Adel Rezaei Moghadam, Zohreh Sanaat, Roya Dolatkhah, Elham Patrad, Mojtaba Amani, Warner Peng, Tuba Esfandyari, Faris Farassati*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
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Translational Therapeutics
A feasibility and randomized phase II study of vorinostat, bevacizumab, or temozolomide during radiation followed by maintenance chemotherapy in newly-diagnosed pediatric high-grade glioma: Children’s Oncology Group study ACNS0822
Lindsey M. Hoffman*, James Geller, James Leach, Daniel Boue, Rachid Drissi, Lu Chen, Mark Krailo, Atmaram Pai Panandiker, Lionel Chow, Daphne Haas-Kogan, Sachin Jogal, Marvin Nelson, Reggie Jakacki, Mark Kieran, Kenneth Cohen, Ian Pollack, Amar Gajjar, Maryam Fouladi
Thursday, May 7:  Session 4 - High Grade Glioma  -  1:15pm - 2:25pm
A molecular biology and phase II study of Imetelstat (GRN163L) in children with recurrent or refractory central nervous system (CNS) malignancies: a Pediatric Brain Tumor Consortium Study 
Ralph Salloum*, Trent Hummel, Shiva-Senthil Kumar, Kathleen Dorris, Shaoyu Li, Tong Lin, Arzu Onar-Thomas, Lili Miles, Tina Toung-Poussaint, Charles Stevenson, Stewart Goldman, Girish Dhall, Roger Packer, Paul Fisher, Maryam Fouladi, James Boyett, Rachid Drissi
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Autophagy inhibition reverses resistance to targeted BRAF therapy in pediatric CNS tumors
Shadi Zahedi, Andrea Griesinger, Michael Handler, Nicholas Foreman, Andrew Thorburn, Jean M. Mulcahy Levy*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Combinatorial pathway targeting approaches for BRAF-fusions associated with pediatric low-grade gliomas
Angela Waanders, Amanda Silva, Shih-Shan Chen, Harry Han, Yuankun Zhu, Katie Boucher, Payal Jain*, Tamara Fierst, Namrata Choudhari, Sabine Mueller, Daphne Haas-Kogan, Phillip Storm, Adam Resnick
Thursday, May 7:  Session 5 - Low Grade Glioma  -  2:15pm - 3:15pm
Effects of everolimus on meningioma growth in patients with neurofibromatosis Type 2
Diana Osorio*, Alexander Filatov, Mari Hagiwara, Carole Mitchell, Jeffrey Wisoff, John Golfinos, J. Thomas Roland, Jeffrey Allen, Matthias Karajannis
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
ER stress inducing drugs downregulates MGMT and MPG sensitizing pediatric glioma cell lines to TMZ
Enric Xipell*, Naiara Martinez-Vélez, Marisol Gonzalez-Huarriz, Arlet Acanda de la Rocha, Chris Jones, Marta M. Alonso
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Ezh2, a novel target in treatment of medulloblastoma
Brandon Ricke, Kushal Shah, Michael Salacz, Paul Camarata, Darren Lovick, Warner Peng, Roya Dolatkhah, Zohreh Sanaat, Kyle Kimura*, Danse Bi, Sarah Taylor, Tuba Esfandyari, Faris Farassati
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Immunotargeted-molecular-robotic-nanosurgery(ITMRN) eradicates GBM stem-cells with radiofrequency dielectric heating(RFDH) mediated via silver-immunonanobots linked with anti-CD133 MAbs
John Giannios*
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Inhibition of AKT signaling and tumor growth by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cell line in vitro and in nude mice xenografts
Cheppail Ramachandran*, Gilda Portalatin, Karl-Werner Quirin, Enrique Escalon, Ziad Khatib, Steven Melnick
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
LB100, a novel protein phosphatase 2A inhibitor, enhances cisplatin and radiation mediated cytotoxicity and overcome cisplatin resistance in-vitro
Sze Chun Winson Ho*, Michael Feldman, Dragan Maric, John Heiss, Zhengping Zhuang
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Nanoparticle siRNA delivery vehicles inhibit DNA repair and sensitize pediatric brain tumor cells to radiation therapy
Forrest Kievit*, Zachary Stephen, Kui Wang, Christopher Dayringer, John Silber, Richard Ellenbogen, Miqin Zhang
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
OKN-007: a novel compound for treating pediatric glioblastoma
Samantha Mallory*, Rene McNall-Knapp, Patricia Coutinho DeSouza, Nataliya Smith, Debra Saunders, Kar-Ming Fung, Rheal Towner
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Personalized targeted therapy in refractory or relapsed cancer in childhood (Triceps Study)
Sophie DUMOUCEL*, Michel DUVAL, Monia MARZOUKI, Henrique BITTENCOURT, Yvan SAMSON, Sonia CELLOT, Georges-Etienne RIVARD, Pierre TEIRA, Anne-Sophie CARRET, Jasmine HEALY, Dorothee DAL SOGLIO, Natacha PATEY, Nelson PICHE, Thomas SONTAG, Sylvie LANGLOIS, Mathieu LAJOIE, Daniel SINNETT
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Pharmacological modulation of blood-brain barrier: a novel therapeutic approach to refractory CNS tumors
Sabrina Becciani, Martina Da Ros*, Anna Lisa Iorio, Laura Giunti, Alessia Stival, Maurizio Lucchesi, Maura Massimino, Maurizio de Martino, Iacopo Sardi
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Targeted combinatorial approach for treatment of pediatric low grade gliomas in the context of BRAFV600E and KIAA1549:BRAF mutations
Aleksandra K. Olow*, Sabine Mueller, Xiaodong Yang, Rintaro Hashizume, Justin Meyerowitz, William Weiss, Adam C. Resnick, Angela J. Waanders, Mitchel S. Berger, Nalin Gupta, C. David James, Daphne A. Haas-Kogan
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
The effect of regadenoson-induced transient disruption of the blood brain barrier on temozolomide delivery to rat brain parenchyma
Sadhana Jackson*, Nicole Anders, Antonella Mangraviti, Henry Brem, Betty Tyler, Michelle Rudek, Stuart Grossman
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
Use of IV N-acetylcysteine in combination with sodium thiosulfate for prevention of ototoxicity in pediatric patients
Edward Neuwelt*, Nancy Doolittle, Kristin Knight, Susan Lindemulder
Thursday, May 7:  Poster Reception  -  5:30pm - 7:30pm
^Top